Psilocybin is a prodrug that is converted into the pharmacologically active compound psilocin in the body by dephosphorylation. This chemical reaction takes place under strongly acidic conditions or enzymatically by phosphatases in the body. Psilocybin is a zwitterionic alkaloid that is soluble in water, moderately soluble in methanol and ethanol, and insoluble in most organic solvents. Psilocybin can be synthesized in the laboratory from psilocin by a two-step procedure, but this is rarely done since psilocin is the a ...

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Psilocybin, Psilocybin - Chemistry, Psilocybin - Biology, Psilocybin - Pharmacology, Psilocybin - Medicine, Psilocybin - Toxicity, Psilocybin - Effects, Psilocybin - Law, Psilocybin - Media, Psilocybin - References in popular culture

Read more here: » Psilocybin: Encyclopedia II - Psilocybin - Chemistry

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Psilocybin, Psilocybin - Chemistry, Psilocybin - Biology, Psilocybin - Pharmacology, Psilocybin - Medicine, Psilocybin - Toxicity, Psilocybin - Effects, Psilocybin - Law, Psilocybin - Media, Psilocybin - References in popular culture

Read more here: » Psilocybin: Encyclopedia II - Psilocybin - Medicine

Psilocybin is absorbed through the lining of the mouth and stomach. Effects begin 20-45 minutes after ingestion of psilocybin-containing mushrooms, and last from 2-6 hours depending on dose, species, and individual metabolism. If mushrooms are chewed and held in the mouth, or taken as mushroom tea, effects begin slightly sooner and are usually noticeable within 15 minutes. This is typically done in combination with Orange juice or another drink with power taste to dilute the unpleasant taste of Psilocybe mushrooms. Nausea is not uncommon whe ...

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Psilocybin, Psilocybin - Chemistry, Psilocybin - Biology, Psilocybin - Pharmacology, Psilocybin - Medicine, Psilocybin - Toxicity, Psilocybin - Effects, Psilocybin - Law, Psilocybin - Media, Psilocybin - References in popular culture

Read more here: » Psilocybin: Encyclopedia II - Psilocybin - Effects

Baeocystin is a mushroom alkaloid and analog of the psychedelic hallucinogenic drug psilocybin, a tryptamine derivative. It is found as a minor compound in most psychoactive mushrooms together with psilocybin, norbaeocystin, and psilocin. Little information exists with regard to human pharmacology, but a dosage of 10mg is reported to produce entheogenic effects. First isolated from the mushroom psilocybe baeocystis, baeoc ...

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4-Acetoxy-DIPT (4-acetoxy-N,N-diisopropyltryptamine) is a hallucinogenic tryptamine. 15-30mg is usually consumed orally. Effects are said to last 4-8 hours and resemble those of psilocybin mushrooms and iprocin. See also. TiHKAL ...

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Harmala, also known at various times as Telepathine and Banisterine, is a blanket term for a group of naturally occurring beta-carbolines including harmine, harmaline, and others. The harmala alkaloids are monoamine oxidase inhibitors. They also act as serotonin antagonists and CNS stimulants. Harmala is found most commonly in the seeds of the Middle Eastern plant Harmal (Peganum harmala, from which the name derives), commonly known as Syrian Rue. It occurs in the seeds in concentrations of roughly 3%, thou ...

Including:

• Harmala - Telepathine
• Harmala - Uses
• Harmala - Chemical Forms

Read more here: » Harmala: Encyclopedia - Harmala

4-HO-DiPT (also known as 4-hydroxy-di-isopropyl-tryptamine, or Iprocin) is a hallucinogenic drug. It is classified as a tryptamine derivative, and as an indole compound. An experience on 4-HO-DiPT can be compared to psilocybin/psilocin, LSD or DMT, which are also tryptamines/indoles. However, the duration of the above mentioned drugs vary considerably. Iprocin is orally active, and 20-25mg represents a fully effective dosage with most users. ...

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Good Friday is a holy day celebrated by Christians on the Friday before Easter or Pascha. It commemorates the crucifixion of Jesus at Calvary. Special prayer services are often held on this day with readings from the Gospel accounts of the events leading up to the crucifixion. Mainstream Christian churches view Christ's crucifixion as a voluntary and vicarious act, and one by which, along with his resurrec ...

Including:

• Good Friday - Jesus's possible death date
• Good Friday - History and observance
• Good Friday - In the Eastern Orthodox & Eastern Catholic Churches
• Good Friday - In the Latin Catholic Church
• Good Friday - An Example: The Philippines
• Good Friday - In Protestantism
• Good Friday - Residual Customs in English-speaking World
• Good Friday - Related holy days

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Wavy cap or Caramel-capped psilocybe (Psilocybe cyanescens) is a psychedelic mushroom whose main active compound is psilocybin. It belongs to the family Strophariaceae in the order Agaricales. Wavy cap - Appearance. Psilocybe cyanescens has a hygrophanous pileus that is fawn-brown when moist, becoming pale ochreous when drying. It bruises with a bluish or blue-green color, often still visible on dried stipe. The mushroom grows to a height of 2-5 cm. Wavy cap - Habi ...

Including:

• Wavy cap - Appearance
• Wavy cap - Habitat
• Wavy cap - Legal Status

Read more here: » Wavy cap: Encyclopedia - Wavy cap

Mescaline or 3,4,5-trimethoxyphenethylamine is a psychedelic hallucinogenic drug and entheogen of the phenethylamine family. It is either synthesized (as mescaline sulfate) or extracted from the peyote cactus (Lophophora williamsii), the San Pedro cactus (Echinopsis pachanoi), or the Peruvian Torch cactus (Echinopsis peruviana). It is also found in a number of other members of the Cactaceae. The use of extract from peyote in Native American religious ceremonies has been noted since the earliest Europ ...

Including:

• Mescaline - Chemistry
• Mescaline - Side Effects
• Mescaline - Positive Side Effects
• Mescaline - Neutral Side Effects
• Mescaline - Negative Side Effects
• Mescaline - Famous Users
• Mescaline - Categorization

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5-MeO-DPT (also known as 5-methoxy-N,N-Dipropyltryptamine, is a hallucinogenic and entheogenic drug. 5-MeO-DPT - Chemistry. The full chemical name is N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-propylpropan-1-amine. It is classified as a tryptamine derivative, and as an indole compound. 5-MeO-DPT - Effects. Little is known about the subjective effects of 5-MeO-DPT, but the nature of the compound probably comparable to psilocybin/psilocin, or DPT, which are also psychedelic try ...

Including:

• 5-MeO-DPT - Chemistry
• 5-MeO-DPT - Effects
• 5-MeO-DPT - Dosage

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Spores of Psilocybe mushrooms can be legally purchased from several mail order sources; however, cultivation and consumption of the mushrooms are illegal in many jurisdictions. Internationally, psilocybin is a Schedule I drug under the Convention on Psychotropic Substances. Parties to the treaty are required to restrict use of the drug to medical and scientific purposes. In Japan, it was legal to possess and sell psilocybin mushrooms until June 2002. Possession was made illegal in 2002, possibly in preparation for the Wor ...

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Psilocybin, Psilocybin - Chemistry, Psilocybin - Biology, Psilocybin - Pharmacology, Psilocybin - Medicine, Psilocybin - Toxicity, Psilocybin - Effects, Psilocybin - Law, Psilocybin - Media, Psilocybin - References in popular culture

Read more here: » Psilocybin: Encyclopedia II - Psilocybin - Law

Psilocybin acts as an agonist for the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT). It binds to 5-HT receptors in the brain, and mimics the effects of serotonin. While psilocybin may deliver a stronger impulse to the postsynaptic receptor than serotonin does, mostly the effect is a product of the fact that there is now both serotonin and a serotonin agonist in the synapse (this is equivalent to having twice as much serotonin in the synapse). Compare this effect to that of MDMA, which increases the amount of actual se ...

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Psilocybin, Psilocybin - Chemistry, Psilocybin - Biology, Psilocybin - Pharmacology, Psilocybin - Medicine, Psilocybin - Toxicity, Psilocybin - Effects, Psilocybin - Law, Psilocybin - Media, Psilocybin - References in popular culture

Read more here: » Psilocybin: Encyclopedia II - Psilocybin - Pharmacology

Please read under psilocybin for more details. Psilocin is the pharmacologically active agent in the body after ingestion of psilocybin or hallucinogenic mushrooms. ...

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Psilocin, Psilocin - History, Psilocin - Chemistry, Psilocin - Pharmacology

Read more here: » Psilocin: Encyclopedia II - Psilocin - Pharmacology

Dosage of psychedelic mushrooms depends on the total psilocybin and psilocin content of the mushrooms, which varies significantly between species and can also vary significantly within the same species, but is typically around 0.5-2% of the dried weight of the mushroom. A light dose of P. cubensis is usually cited to be about 1g dried material, corresponding to approximately 10mg of psilocybin/psilocin. A common or average dose is approximately 1-3g, corresponding to 10-30mg psilocybin/psilocin and a heavy dose is about 3-5g dried mat ...

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Psychedelic mushroom, Psychedelic mushroom - History, Psychedelic mushroom - Effects, Psychedelic mushroom - Dosage, Psychedelic mushroom - Legal Status, Psychedelic mushroom - Nomenclature, Psychedelic mushroom - Books

Read more here: » Psychedelic mushroom: Encyclopedia II - Psychedelic mushroom - Dosage

The fly-agaric is not a controlled substance in most countries. Access to ergot and ergoline alkaloids is usually restricted since these substances are precursors to LSD. In most western countries, possession and use of psilocybin mushrooms is illegal. An exception to that rule are The Netherlands, where fresh mushrooms can be obtained in so-called "smart shops" which specialize in ethnobotanicals. Dried mushrooms however are considered a "preparation" and thus remain illegal, even in Holland; the same law is currently in place ...

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Psychedelic mushroom, Psychedelic mushroom - History, Psychedelic mushroom - Effects, Psychedelic mushroom - Dosage, Psychedelic mushroom - Legal Status, Psychedelic mushroom - Nomenclature, Psychedelic mushroom - Books

Read more here: » Psychedelic mushroom: Encyclopedia II - Psychedelic mushroom - Legal Status

LSD is, by weight, one of the most potent drugs yet discovered. Both subjective reports and pharmacological methods such as receptor binding assays determine LSD to be, per mole, around 100 times more potent than psilocybin and psilocin and around 4000 times more potent than mescaline. Dosages of LSD are measured in micrograms (µg), or millionths of a gram. By comparison, dosages of almost all other drugs, both recreational and medica ...

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LSD, LSD - Origin, LSD - Dosage, LSD - Effects, LSD - Physical, LSD - Pharmacological, LSD - Psychological, LSD - Acute duration, LSD - Physical dangers, LSD - Flashbacks, LSD - Psychosis, LSD - Addiction potential, LSD - Possible medical uses, LSD - Chemistry, LSD - Forms of LSD, LSD - Legal status, LSD - LSD in the United States, LSD - Notable people who have commented on the LSD experience, LSD - Chemical, LSD - People, LSD - Other

Read more here: » LSD: Encyclopedia II - LSD - Dosage

Illegal drug trade - Anabolic steroids. For detailed information on anabolic steroids, see the Anabolic steroids article. Illegal use of anabolic steroids, a class of hormones, is primarily to improve the muscular system of the human body for either increased performance (for example by athletes) or better bodybuilding results. Anabolic steroids are not known to be chemically addictive, but can be psycho ...

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Illegal drug trade, Illegal drug trade - Manufacturing and processing, Illegal drug trade - Distribution and wholesaling, Illegal drug trade - Retail selling, Illegal drug trade - Availability of controlled substances over the Internet, Illegal drug trade - Rising influence of Mexican cartels in drug trafficking in the U.S., Illegal drug trade - Punishments in various countries, Illegal drug trade - Australia, Illegal drug trade - The Netherlands, Illegal drug trade - Indonesia, Illegal drug trade - Trade of specific drugs, Illegal drug trade - Anabolic steroids, Illegal drug trade - Cannabis, Illegal drug trade - LSD, Illegal drug trade - Psilocybin mushrooms, Illegal drug trade - Alcohol, Illegal drug trade - Tobacco, Illegal drug trade - Cocaine, Illegal drug trade - Crack cocaine, Illegal drug trade - Heroin and opium, Illegal drug trade - Methamphetamine

Read more here: » Illegal drug trade: Encyclopedia II - Illegal drug trade - Trade of specific drugs

Many people do not find the hard/soft drug distinction useful, as it is the drug users' behavior that is the most important determinate of harm, not the choice of drug: all drugs can be harmful if misused. A more useful distinction ranks drugs according to their toxicity and addictive potential. However, the legal treatment of drugs still seems influenced by perception rather than fact, so this article will group the discussion accordingly. "Soft" drugs are generally drugs which are perceived to have less potential for causing physica ...

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Illegal drug trade, Illegal drug trade - Soft drugs, Illegal drug trade - Anabolic steroids trade, Illegal drug trade - Cannabis trade, Illegal drug trade - Ecstasy MDMA trade, Illegal drug trade - Ketamine trade, Illegal drug trade - LSD trade, Illegal drug trade - GHB trade, Illegal drug trade - PCP trade, Illegal drug trade - Psilocybin Mushroom trade, Illegal drug trade - Illegal alcohol trade, Illegal drug trade - Illegal tobacco trade, Illegal drug trade - Hard drugs, Illegal drug trade - Cocaine trade, Illegal drug trade - Crack Cocaine trade, Illegal drug trade - Heroin and opium trade, Illegal drug trade - Methamphetamine trade, Illegal drug trade - Manufacturing and processing, Illegal drug trade - Distribution and wholesaling, Illegal drug trade - Retail selling, Illegal drug trade - Rising influence Of Mexican cartels in drug trafficking in the U.S., Illegal drug trade - Punishments in various countries, Illegal drug trade - Australia, Illegal drug trade - The Netherlands/Holland, Illegal drug trade - Indonesia

Read more here: » Illegal drug trade: Encyclopedia II - Illegal drug trade - Soft drugs

'Hard drugs' are generally drugs considered to create a high degree of physical dependence (i.e. addiction) or considered to be a serious detriment to society or personal health. Illegal supply of these so called hard drugs is driven mainly by the economics of drug prohibition coupled with the addiction of their users, with huge profit margins available due to the collision of high demand for the drugs with harsh laws that attempt to prohibit their supply and use. The vast profits on offer mean that the trade is run by highly or ...

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Illegal drug trade, Illegal drug trade - Soft drugs, Illegal drug trade - Anabolic steroids trade, Illegal drug trade - Cannabis trade, Illegal drug trade - Ecstasy MDMA trade, Illegal drug trade - Ketamine trade, Illegal drug trade - LSD trade, Illegal drug trade - GHB trade, Illegal drug trade - PCP trade, Illegal drug trade - Psilocybin Mushroom trade, Illegal drug trade - Illegal alcohol trade, Illegal drug trade - Illegal tobacco trade, Illegal drug trade - Hard drugs, Illegal drug trade - Cocaine trade, Illegal drug trade - Crack Cocaine trade, Illegal drug trade - Heroin and opium trade, Illegal drug trade - Methamphetamine trade, Illegal drug trade - Manufacturing and processing, Illegal drug trade - Distribution and wholesaling, Illegal drug trade - Retail selling, Illegal drug trade - Rising influence Of Mexican cartels in drug trafficking in the U.S., Illegal drug trade - Punishments in various countries, Illegal drug trade - Australia, Illegal drug trade - The Netherlands/Holland, Illegal drug trade - Indonesia

Read more here: » Illegal drug trade: Encyclopedia II - Illegal drug trade - Hard drugs