Lorazepam - Pharmacological Data and Pharmacokinetics

Lorazepam is a benzodiazepine used to treat anxiety disorders and insomnia, as well as certain types of seizures. It is sold under the brand names Ativan®, Temesta®, Tavor® (in Europe) and as generic lorazepam. It is available in tablets and as a solution for intramuscular and intravenous injections. Its formula is C15H10Cl2N2O2 and its CAS number is 846-49-1. Pharmacologically it is classified as a sedative-hypnotic, anxiolytic and anticonvulsant.Including:

• Lorazepam - Indications
• Lorazepam - Pharmacological Data and Pharmacokinetics
• Lorazepam - Dosage
• Lorazepam - Disadvantages
• Lorazepam - Abuse
• Lorazepam - Legal issues

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Lorazepam is rapidly and nearly completely absorbed after any mode of application (oral, sublingual, i.m., i.v.). After i.v.-injection onset of action is within minutes and may be delayed to 30-45 minutes after oral/sublingual dose and up to 1 hour after i.m. use. The duration of action depends on the dose and is normally 6 to 12 hours. The half-life of lorazepam in patients with normal liver function is 11 to 18 hours. Therefore, 2-4 daily doses are often needed. A dose equivalent to 5 mg of diazepam is 500 micrograms (0.5 mg) of lorazepam. [1]. Other experts estim ...

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Lorazepam, Lorazepam - Indications, Lorazepam - Pharmacological Data and Pharmacokinetics, Lorazepam - Dosage, Lorazepam - Disadvantages, Lorazepam - Abuse, Lorazepam - Legal issues

Read more here: » Lorazepam: Encyclopedia II - Lorazepam - Pharmacological Data and Pharmacokinetics

Daily doses vary greatly from 0.5 mg bedtime for insomnia and 2.5 mg every 6 hours and more in the acute treatment of mania, before the firstline drugs (lithium, valproic acid) control the situation. Catatonia with inability to speak is very responsive and sometimes controlled with a single dose of 2 mg oral or slow i.v. injection. Catatonia may reoccur and treatment for some days may be necessary. Sometimes haloperidol is given concomitantly. The control of status epilepticus requires slow i.v. injections of 2 to 4 (or even 8) mg. Patients should be closely monitored for respiratory ...

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Lorazepam, Lorazepam - Indications, Lorazepam - Pharmacological Data and Pharmacokinetics, Lorazepam - Dosage, Lorazepam - Disadvantages, Lorazepam - Abuse, Lorazepam - Legal issues

Read more here: » Lorazepam: Encyclopedia II - Lorazepam - Dosage

Lorazepam, like other benzodiazepines, can cause psychological and/or physical dependence. Withdrawal symptoms are similar in character to those of alcohol and barbiturates have been observed after abrupt discontinuation, therefore, a gradual taper is recommended over a period of weeks or even months, depending on the length of time it was used and the dosage taken. The likelihood of abuse, dependence and withdrawal symptoms is substantially greater with lorazepam relative to other benzodiazepines because of its short half-life, highe ...

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Lorazepam, Lorazepam - Indications, Lorazepam - Pharmacological Data and Pharmacokinetics, Lorazepam - Dosage, Lorazepam - Disadvantages, Lorazepam - Abuse, Lorazepam - Legal issues

Read more here: » Lorazepam: Encyclopedia II - Lorazepam - Disadvantages