hypercholesterolemia

Fibrates are used as accessory therapy in many forms of hypercholesterolemia, usually in combination with statins. Trials do support its use as monotherapy. Although less effective in lowering LDL, fibrates improve HDL and triglyceride levels, and seem to improve insulin resistance when the dyslipidemia is associated with other features of Syndrome X (hypertension and diabetes mellitus type 2). ...

See also:

Fibrate, Fibrate - Members, Fibrate - Uses, Fibrate - Side-effects, Fibrate - Pharmacology

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The Scandinavian Simvastatin Survival Study (also known under the abbreviation 4S) is a multicenter clinical trial that was performed in 1990s in Scandinavia. The objective of the study was to assess effect of cholesterol-lowering drug called simvastatin on mortality and morbidity in group of 4444 patients with coronary heart disease, aged between 35 and 70 years. The patients presented with moderate hypercholesterolemia between 5.5 and 8.0 mmol/l. The results of the trial showed that treatment of patients with simvastatin patients sufferi ...

Including:

• Scandinavian Simvastatin Survival Study - References

Read more here: » Scandinavian Simvastatin Survival Study: Encyclopedia - Scandinavian Simvastatin Survival Study

Cholesterol is a steroid, a lipid, and an alcohol, found in the cell membranes of all body tissues, and transported in the blood plasma of all animals. Most cholesterol is not dietary in origin, it is synthesized internally. Cholesterol is present in higher concentrations in tissues which either produce more or have more densely-packed membranes, for example, the liver, spinal cord, brain and atheroma. Cholesterol plays a central role in many biochemical processes, but is best known for the association of cardiovascular disease with v ...

Including:

• Cholesterol - History of the name
• Cholesterol - Physiology
• Cholesterol - Synthesis and intake
• Cholesterol - Properties
• Cholesterol - Regulation
• Cholesterol - Function
• Cholesterol - Excretion
• Cholesterol - Role in atheromatous disease
• Cholesterol - Cholesteric liquid crystals
• Cholesterol - Sources

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In pharmacology, bile acid sequestrants are a group of medications used for binding bile in the gastrointestinal tract, used for the treatment of hypercholesterolemia and the prevention of pruritus (itch) in patients with chronic liver disease or diarrhea. Two drugs are members of this class; both are synthetic resins: Cholestyramine (Questran®) Colestipol (Colestid®) Use of these agents has decreased markedly since the introduction of statins. They are occasionally used as an adjunctive to ...

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Cholestyramine (Questran®, Questran Light®, Cholybar®) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It increases removal of bile acids from body by forming insoluble complexes in intestine, which are then excreted in feces. As body loses bile acids, it converts cholesterol from blood to bile acid, thus lowering serum cholesterol. It is primarily used to treat hypercholesterolemia, but can also used to treat the pruritus, or itching, that often occurs during liver fa ...

Including:

• Cholestyramine - Available forms
• Cholestyramine - Dosage

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Although used clinically since the early 1970s, the mechanism of action of fibrates remained unelucidated until, in the 1990s, it was discovered that fibrates activate PPAR (peroxisome proliferator-activated receptors), especially PPARα. The PPARs are a class of intracellular receptors that modulate carbohydrate, fat metabolism and adipose tissue differentiation. Activation of PPARs causes transcription of a number of genes on the DNA that facilitate lipid metabolism. Fibrates are structurally and pharmacologically related to the thiazolidinediones, a novel class of anti-diabetic drugs that also ...

See also:

Fibrate, Fibrate - Members, Fibrate - Uses, Fibrate - Side-effects, Fibrate - Pharmacology

Read more here: » Fibrate: Encyclopedia II - Fibrate - Pharmacology

In medicine, combined hyperlipidemia (or -aemia) is a commonly occurring form of hypercholesterolemia (elevated cholesterol levels) characterised by increased LDL and triglyceride concentrations, often accompanied by decreased HDL. On lipoprotein electrophoresis (a test now rarely performed) is shows as a hyperlipoproteinemia type IIB. The elevated triglyceride levels (>5 mmol/l) are generally due to an increase in VLDL (very low density lipoprotein), ...

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Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis (idiosyncratic destruction of muscle tissue, leading to renal failure). A powerful statin drug, cerivastatin (Lipobay®), was withdrawn because of this complication. The less lipophilic statins are less prone to cause this reaction, and are pro ...

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Fibrate, Fibrate - Members, Fibrate - Uses, Fibrate - Side-effects, Fibrate - Pharmacology

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The most common cause of a TIA is an embolus (a small blood clot) that occludes an artery in the brain. This most frequently arises from an atherosclerotic plaque in one of the carotid arteries or from a thrombus in the heart due to atrial fibrillation. Other reasons include excessive narrowing of large vessels due to an atherosclerotic plaque and increased blood viscosity due to some blood diseases. TIA is related with other medical conditions like hypertension, heart disease (especially atrial fibrillation), migraine, cigarette s ...

See also:

Transient ischemic attack, Transient ischemic attack - Symptoms, Transient ischemic attack - Prognosis, Transient ischemic attack - Causes, Transient ischemic attack - Treatment

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Myocardial infarction - Ischemia and infarction. The underlying mechanism of a heart attack is the destruction of heart muscle cells due to a lack of oxygen. If these cells are not supplied with sufficient oxygen by the coronary arteries to meet their metabolic demands, they die by a process called infarction. The decrease in blood supply has the following consequences: Heart muscle which has lost blood flow long enough, e.g. 10-15 minutes, dies (necrosis) and does not grow back. A collagen sc ...

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Myocardial infarction, Myocardial infarction - Symptoms, Myocardial infarction - Diagnosis, Myocardial infarction - Electrocardiogram, Myocardial infarction - Myocardial markers, Myocardial infarction - Pathophysiology, Myocardial infarction - Ischemia and infarction, Myocardial infarction - Atherosclerosis / other predisposing factors, Myocardial infarction - First aid, Myocardial infarction - Immediate care, Myocardial infarction - Emergency services, Myocardial infarction - Wilderness first aid, Myocardial infarction - Air travel, Myocardial infarction - Treatment, Myocardial infarction - First line, Myocardial infarction - Reperfusion, Myocardial infarction - Monitoring and follow-up, Myocardial infarction - History

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LGS seizures are often treatment resistant, but this does not mean that treatment is futile. Lennox-Gastaut syndrome - Pharmacological. valproates (valproic acid, sodium valproate and valproate semisodium) benzodiazepines, specifically clonazepam, nitrazepam, and clobazam In 1999, Dr. Sachdeo and colleagues at the University of Medicine and Dentistry of New Jersey and the Robert Wood Johnson Medical School in New Brunswick reported that 33% of the patien ...

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Lennox-Gastaut syndrome, Lennox-Gastaut syndrome - Characteristics, Lennox-Gastaut syndrome - Incidence and Prevalence, Lennox-Gastaut syndrome - Finland, Lennox-Gastaut syndrome - United States, Lennox-Gastaut syndrome - Mortality and Morbidity, Lennox-Gastaut syndrome - Causes, Lennox-Gastaut syndrome - Diagnosis, Lennox-Gastaut syndrome - Treatment, Lennox-Gastaut syndrome - Pharmacological, Lennox-Gastaut syndrome - Surgical, Lennox-Gastaut syndrome - Other, Lennox-Gastaut syndrome - Prognosis, Lennox-Gastaut syndrome - History, Lennox-Gastaut syndrome - End notes

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There are several ways in which a language can exhibit synthetic characteristics: Synthetic language - Derivational synthesis. In derivational synthesis, morphemes of different types (nouns, verbs, affixes, etc.) are joined to create new words. For example: German: Luftkissenfahrzeug "air-cushion-travel-machine" = "hovercraft" Greek: υπερχοληστερολαιμία "overmuch/high-cholesterol-blood" = "hypercholesterolemia" Japanese: teishaekiSee also:

Synthetic language, Synthetic language - Synthetic and isolating languages, Synthetic language - Specimens, Synthetic language - Forms of synthesis, Synthetic language - Derivational synthesis, Synthetic language - Relational synthesis, Synthetic language - Degrees of synthesis, Synthetic language - Strictly isolating, Synthetic language - Rather isolating, Synthetic language - Rather synthetic, Synthetic language - Very synthetic, Synthetic language - Polysynthetic, Synthetic language - Oligosynthesis

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List of ICD-9 codes - Intestinal infectious diseases 001-009. (001) Cholera (002) Typhoid and paratyphoid fevers (003) Other Salmonella infections (003.0) Salmonella gastroenteritis (004) Shigellosis (004.9) Shigellosis, unspec. (005) Other food poisoning (bacterial) (005.0) Staphylococcal food poisoning (006) Amoebiasis (006.0) Acute amoebic dysentery without mention of abscess (006 ...

See also:

List of ICD-9 codes, List of ICD-9 codes - 1. Infectious and parasitic diseases 001-139, List of ICD-9 codes - Intestinal infectious diseases 001-009, List of ICD-9 codes - tuberculosis 010-018, List of ICD-9 codes - zoonotic bacterial diseases 020-027, List of ICD-9 codes - other bacterial diseases 030-041, List of ICD-9 codes - human immunodeficiency virus hiv infection 042-044, List of ICD-9 codes - poliomyelitis and other non-arthropod-borne viral diseases of central nervous system 045-049, List of ICD-9 codes - viral diseases accompanied by exanthem 050-057, List of ICD-9 codes - arthropod-borne viral diseases 060-066, List of ICD-9 codes - other diseases due to viruses and chlamydiae 070-079, List of ICD-9 codes - rickettsioses and other arthropod-borne diseases 080-088, List of ICD-9 codes - syphilis and other venereal diseases 090-099, List of ICD-9 codes - other spirochetal diseases 100-104, List of ICD-9 codes - mycoses 110-118, List of ICD-9 codes - helminthiases 120-129, List of ICD-9 codes - other infectious and parasitic diseases 130-136, List of ICD-9 codes - late effects of infectious and parasitic diseases 137-139, List of ICD-9 codes - 2. Neoplasms 140-239, List of ICD-9 codes - malignant neoplasm of lip oral cavity and pharynx 140-149, List of ICD-9 codes - malignant neoplasm of digestive organs and peritoneum 150-159, List of ICD-9 codes - malignant neoplasm of respiratory and intrathoracic organs 160-165, List of ICD-9 codes - malignant neoplasm of bone connective tissue skin and breast 170-176, List of ICD-9 codes - malignant neoplasm of genitourinary organs 179-189, List of ICD-9 codes - malignant neoplasm of other and unspecified sites 190-199, List of ICD-9 codes - malignant neoplasm of lymphatic and hematopoietic tissue 200-208, List of ICD-9 codes - benign neoplasms 210-229, List of ICD-9 codes - carcinoma in situ 230-234, List of ICD-9 codes - neoplasms of uncertain behavior 235-238, List of ICD-9 codes - neoplasms of unspecified nature 239-239, List of ICD-9 codes - 3. Endocrine nutritional and metabolic diseases and immunity disorders 240-279, List of ICD-9 codes - disorders of thyroid gland 240-246, List of ICD-9 codes - diseases of other endocrine glands 250-259, List of ICD-9 codes - nutritional deficiencies 260-269, List of ICD-9 codes - other metabolic and immunity disorders 270-279, List of ICD-9 codes - 4. Diseases of the blood and blood-forming organs 280-289, List of ICD-9 codes - diseases of the blood and blood-forming organs 280-289, List of ICD-9 codes - 5. Mental disorders 290-319, List of ICD-9 codes - psychoses 290-299, List of ICD-9 codes - organic psychotic conditions 290-294, List of ICD-9 codes - other psychoses 295-299, List of ICD-9 codes - neurotic disorders personality disorders and other nonpsychotic mental disorders 300-316, List of ICD-9 codes - mental retardation 317-319, List of ICD-9 codes - 6. Diseases of the nervous system and sense organs 320-389, List of ICD-9 codes - inflammatory diseases of the central nervous system 320-326, List of ICD-9 codes - hereditary and degenerative diseases of the central nervous system 330-337, List of ICD-9 codes - other disorders of the central nervous system 340-349, List of ICD-9 codes - disorders of the peripheral nervous system 350-359, List of ICD-9 codes - disorders of the eye and adnexa 360-379, List of ICD-9 codes - diseases of the ear and mastoid process 380-389, List of ICD-9 codes - 7. Diseases of the circulatory system 390-459, List of ICD-9 codes - acute rheumatic fever 390-392, List of ICD-9 codes - chronic rheumatic heart disease 393-398, List of ICD-9 codes - hypertensive disease 401-405, List of ICD-9 codes - ischemic heart disease 410-414, List of ICD-9 codes - diseases of pulmonary circulation 415-417, List of ICD-9 codes - other forms of heart disease 420-429, List of ICD-9 codes - cerebrovascular disease 430-438, List of ICD-9 codes - diseases of arteries arterioles and capillaries 440-448, List of ICD-9 codes - diseases of veins and lymphatics and other diseases of circulatory system 451-459, List of ICD-9 codes - 8. Diseases of the respiratory system 460-519, List of ICD-9 codes - acute respiratory infections 460-466, List of ICD-9 codes - other diseases of the upper respiratory tract 470-478, List of ICD-9 codes - pneumonia and influenza 480-487, List of ICD-9 codes - chronic obstructive pulmonary disease and allied conditions 490-496, List of ICD-9 codes - pneumoconioses and other lung diseases due to external agents 500-508, List of ICD-9 codes - other diseases of respiratory system 510-519, List of ICD-9 codes - 9. Diseases of the digestive system 520-579, List of ICD-9 codes - diseases of oral cavity salivary glands and jaws 520-529, List of ICD-9 codes - diseases of esophagus stomach and duodenum 530-537, List of ICD-9 codes - appendicitis 540-543, List of ICD-9 codes - hernia of abdominal cavity 550-553, List of ICD-9 codes - noninfectious enteritis and colitis 555-558, List of ICD-9 codes - other diseases of intestines and peritoneum 560-569, List of ICD-9 codes - other diseases of digestive system 570-579, List of ICD-9 codes - 10. Diseases of the genitourinary system 580-629, List of ICD-9 codes - nephritis nephrotic syndrome and nephrosis 580-589, List of ICD-9 codes - other diseases of urinary system 590-599, List of ICD-9 codes - diseases of male genital organs 600-608, List of ICD-9 codes - disorders of breast 610-611, List of ICD-9 codes - inflammatory disease of female pelvic organs 614-616, List of ICD-9 codes - other disorders of female genital tract 617-629, List of ICD-9 codes - 11. Complications of pregnancy childbirth and the puerperium 630-676, List of ICD-9 codes - ectopic and molar pregnancy 630-633, List of ICD-9 codes - other pregnancy with abortive outcome 634-639, List of ICD-9 codes - complications mainly related to pregnancy 640-648, List of ICD-9 codes - normal delivery and other indications for care in pregnancy labor and delivery 650-659, List of ICD-9 codes - complications occurring mainly in the course of labor and delivery 660-669, List of ICD-9 codes - complications of the puerperium 670-676, List of ICD-9 codes - 12. Diseases of the skin and subcutaneous tissue 680-709, List of ICD-9 codes - infections of skin and subcutaneous tissue 680-686, List of ICD-9 codes - other inflammatory conditions of skin and subcutaneous tissue 690-698, List of ICD-9 codes - other diseases of skin and subcutaneous tissue 700-709, List of ICD-9 codes - 13. Diseases of the musculoskeletal system and connective tissue 710-739, List of ICD-9 codes - arthropathies and related disorders 710-719, List of ICD-9 codes - dorsopathies 720-724, List of ICD-9 codes - rheumatism excluding the back 725-729, List of ICD-9 codes - osteopathies chondropathies and acquired musculoskeletal deformities 730-739, List of ICD-9 codes - 14. Congenital anomalies 740-759, List of ICD-9 codes - congenital anomalies 740-759, List of ICD-9 codes - 15. Certain conditions originating in the perinatal period 760-779, List of ICD-9 codes - maternal causes of perinatal morbidity and mortality 760-763, List of ICD-9 codes - other conditions originating in the perinatal period 764-779, List of ICD-9 codes - 16. Symptoms signs and ill-defined conditions 780-799, List of ICD-9 codes - symptoms 780-789, List of ICD-9 codes - nonspecific abnormal findings 790-796, List of ICD-9 codes - ill-defined and unknown causes of morbidity and mortality 797-799, List of ICD-9 codes - 17. Injury and poisoning 800-999, List of ICD-9 codes - fracture of skull 800-804, List of ICD-9 codes - fracture of neck and trunk 805-809, List of ICD-9 codes - fracture of upper limb 810-819, List of ICD-9 codes - fracture of lower limb 820-829, List of ICD-9 codes - dislocation 830-839, List of ICD-9 codes - sprains and strains of joints and adjacent muscles 840-848, List of ICD-9 codes - intracranial injury excluding those with skull fracture 850-854, List of ICD-9 codes - internal injury of thorax abdomen and pelvis 860-869, List of ICD-9 codes - open wound of head neck and trunk 870-879, List of ICD-9 codes - open wound 870-897, List of ICD-9 codes - open wound of upper limb 880-887, List of ICD-9 codes - open wound of lower limb 890-897, List of ICD-9 codes - injury to blood vessels 900-904, List of ICD-9 codes - late effects of injuries poisonings toxic effects and other external causes 905-909, List of ICD-9 codes - superficial injury 910-919, List of ICD-9 codes - contusion with intact skin surface 920-924, List of ICD-9 codes - crushing injury 925-929, List of ICD-9 codes - effects of foreign body entering through orifice 930-939, List of ICD-9 codes - burns 940-949, List of ICD-9 codes - injury to nerves and spinal cord 950-957, List of ICD-9 codes - certain traumatic complications and unspecified injuries 958-959, List of ICD-9 codes - poisoning by drugs medicinal and biological substances 960-979, List of ICD-9 codes - toxic effects of substances chiefly nonmedicinal as to source 980-989, List of ICD-9 codes - other and unspecified effects of external causes 990-995, List of ICD-9 codes - complications of surgical and medical care not elsewhere classified 996-999, List of ICD-9 codes - E section -- External causes of injury, List of ICD-9 codes - V codes -- Supplementary classification of factors influencing health status and contact with health services

Read more here: » List of ICD-9 codes: Encyclopedia II - List of ICD-9 codes - 1. Infectious and parasitic diseases 001-139

Since its introduction, there has been a large debate surrounding the price for lipid-lowering treatment and its benefits on atherosclerosis. Although this has affected the other statins as well, simvastatin was the first statin drug to be used extensively in clinical practice. A number of large epidemiological studies were conducted to discover which patients would benefit most from statin drugs; most studies involve simvastatin as the study drug. The most influential studies were the Scandinavian Simvastatin Survival Study ( ...

See also:

Simvastatin, Simvastatin - Uses, Simvastatin - Rationing, Simvastatin - Pharmacology, Simvastatin - Marketing

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Neomycin has a broad spectrum of effect, killing both gram-positive and gram-negative bacteria. It is relatively toxic to humans, and some people have allergic reactions to it. Neomycin is used in the laboratory in agar plates when culturing organisms anaerobically. Neomycin stops the growth of gram-negative bacilli and staphylcocci, allowing Streptococcus species to grow more abundantly. ...

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Neomycin, Neomycin - Uses, Neomycin - Spectrum, Neomycin - History

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Mortality in relation to smoking: 50 years' observation on male British doctors Authors: R. Doll, R. Peto, J. Boreham, I. Sutherland Publication data: BMJ 2004;328:1519–33. Description: This is the British doctors study. A prospective clinical trial which has been running from 1951 to 2001, and in 1956 provided convincing statistical evidence that tobacco smoking increases ...

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List of publications in medicine, List of publications in medicine - Foundations, List of publications in medicine - Recent studies, List of publications in medicine - Bioethics, List of publications in medicine - Biostatistics, List of publications in medicine - Embryology, List of publications in medicine - Nutrition, List of publications in medicine - Transfusion medicine, List of publications in medicine - Clinical chemistry, List of publications in medicine - Hematology, List of publications in medicine - Radiology, List of publications in medicine - Interventional radiology, List of publications in medicine - Nuclear Medicine, List of publications in medicine - Anesthesiology, List of publications in medicine - Pain medicine, List of publications in medicine - Dermatology, List of publications in medicine - Emergency medicine, List of publications in medicine - General practice, List of publications in medicine - Geriatrics, List of publications in medicine - Hospital medicine, List of publications in medicine - Intensive care medicine, List of publications in medicine - Internal medicine, List of publications in medicine - Cardiology, List of publications in medicine - Gastroenterology, List of publications in medicine - Endocrinology, List of publications in medicine - Hematology, List of publications in medicine - Infectious diseases, List of publications in medicine - Nephrology, List of publications in medicine - Oncology, List of publications in medicine - Pulmonology, List of publications in medicine - Rheumatology, List of publications in medicine - Neurology, List of publications in medicine - Obstetrics, List of publications in medicine - gynecology, List of publications in medicine - Palliative care, List of publications in medicine - Pediatrics, List of publications in medicine - public health, List of publications in medicine - Psychiatry, List of publications in medicine - Radiation therapy, List of publications in medicine - General surgery, List of publications in medicine - Neurosurgery, List of publications in medicine - Ophthalmology, List of publications in medicine - Orthopedic surgery, List of publications in medicine - Otolaryngology, List of publications in medicine - Plastic surgery, List of publications in medicine - Urology, List of publications in medicine - Vascular surgery, List of publications in medicine - hyperbaric medicine, List of publications in medicine - Medical informatics, List of publications in medicine - Nosology

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There have been a number of clinical studies, with both human and animal subjects, on the effects of policosanol and on its major component, octanosol. They have found that it can lower cholesterol, act as an anticoagulant, and inhibit atherosclerosis. In one recent double-blind study, patients with high LDL-cholesterol received daily doses of either 10 mg policosanol , 20 mg lovastatin, or 10 mg simvastatin for eight weeks. LDL-cholesterol was reduced by 24% in the policosanol groups, 22% in the lovastatin group and 15% in the simvas ...

See also:

Policosanol, Policosanol - Physical properties, Policosanol - Mechanism of action, Policosanol - Studies, Policosanol - Other claims, Policosanol - Production

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The glomeruli of the kidneys are the parts that normally filter the blood. They consist of capillaries that are fenestrated (leaky, due to little holes called fenestrae or windows) and that allow fluid, salts, and other small solutes to flow through, but normally not proteins. In nephrotic syndrome, the glomeruli become damaged due to diabetes, glomerulonephritis, or even prolonged hypertension (high blood pressure) so that small proteins, such ...

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Nephrotic syndrome, Nephrotic syndrome - Signs and symptoms, Nephrotic syndrome - Diagnosis, Nephrotic syndrome - Pathogenesis, Nephrotic syndrome - Differential diagnosis, Nephrotic syndrome - Treatment, Nephrotic syndrome - Prognosis, Nephrotic syndrome - Reference

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Dehydroepiandrosterone sulfate (DHEAS) is the sulfated version of DHEA, - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small instestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. While DHEA levels reach their peak in the early morning hours, DHEAS levels show no diurnal variation. DHEAS is biologically active only after its su ...

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Dehydroepiandrosterone, Dehydroepiandrosterone - DHEA-DHEAS, Dehydroepiandrosterone - Production, Dehydroepiandrosterone - Role of DHEA, Dehydroepiandrosterone - Disputed effects of DHEA, Dehydroepiandrosterone - Effects of DHEA, Dehydroepiandrosterone - Precautions, Dehydroepiandrosterone - Contraindication, Dehydroepiandrosterone - Increasing endogenous DHEA production, Dehydroepiandrosterone - Metabolites

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Muesli was invented in 1900 by Swiss doctor Maximilian Bircher-Benner for patients in his hospital. The term is a Swiss German diminutive of the German noun "mus", a cooking term for a semi-liquid made from raw or cooked fruit that lacks an exact English equivalent, but that is related to mush, paste, compote or the French purée. Muesli - Original Bircher-Benner muesli recipe. The original Bircher-Benner recipe is still a prototype for most fresh muesli today (serves 1): 1 tablespoon rolled o ...

See also:

Muesli, Muesli - Dry muesli, Muesli - Fresh muesli, Muesli - History, Muesli - Original Bircher-Benner muesli recipe, Muesli - Health benefits

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