Cyclophosphamide - Pharmacokinetics

Cyclophosphamide Cyclophosphamide is a nitrogen mustard alkylating agent, used to treat various types of cancer and some autoimmune disorders. It is a "prodrug"; it is converted in the liver to active forms that have chemotherapeutic activity. Cyclophosphamide - Uses. The main use of cyclophosphamide is together with other chemotherapy agents in the treatment of lymphomas, some forms of leukemia and some solid tumors. In addition, its use is becoming more common in autoimmune dis ...

Including:

• Cyclophosphamide - Uses
• Cyclophosphamide - Pharmacokinetics
• Cyclophosphamide - Mode of action
• Cyclophosphamide - Side-effects
• Cyclophosphamide - History
• Cyclophosphamide - Reference

Read more here: » Cyclophosphamide: Encyclopedia - Cyclophosphamide

The main use of cyclophosphamide is together with other chemotherapy agents in the treatment of lymphomas, some forms of leukemia and some solid tumors. In addition, its use is becoming more common in autoimmune diseases where disease-modifying antirheumatic drugs (DMARDs) have been ineffective. Systemic lupus erythematosus (SLE) with severe lupus nephritis, for example, may respond to pulsed cyclophosphamide. ...

See also:

Cyclophosphamide, Cyclophosphamide - Uses, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Mode of action, Cyclophosphamide - Side-effects, Cyclophosphamide - History, Cyclophosphamide - Reference

Read more here: » Cyclophosphamide: Encyclopedia II - Cyclophosphamide - Uses

The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells which have low levels of aldehyde dehydrogenase. Phosphoramide mustard forms DNA crosslinks between and within DNA strands. This leads to cell death. Cyclophosphamide has relatively little typical chemotherapy toxicity, as ALDH is present in relatively large concentrations in bone marrow stem cells, liver and intestinal epithelium, prot ...

See also:

Cyclophosphamide, Cyclophosphamide - Uses, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Mode of action, Cyclophosphamide - Side-effects, Cyclophosphamide - History, Cyclophosphamide - Reference

Read more here: » Cyclophosphamide: Encyclopedia II - Cyclophosphamide - Mode of action

Side-effects include chemotherapy-induced nausea and vomiting (CINV), bone marrow suppression, alopecia (hair loss) and lethargy. Hemorrhagic cystitis is a frequent complication, but this is prevented by adequate fluid intake and mesna (sodium 2-mercaptoethane sulfonate). Mesna is a sulfhydryl donor and binds acrolein. Cyclophosphamide is itself carcinogenic, potentially causing transitional cell carc ...

See also:

Cyclophosphamide, Cyclophosphamide - Uses, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Mode of action, Cyclophosphamide - Side-effects, Cyclophosphamide - History, Cyclophosphamide - Reference

Read more here: » Cyclophosphamide: Encyclopedia II - Cyclophosphamide - Side-effects