Cyclophosphamide Cyclophosphamide is a nitrogen mustard alkylating agent, used to treat various types of cancer and some autoimmune disorders. It is a "prodrug"; it is converted in the liver to active forms that have chemotherapeutic activity. Cyclophosphamide - Uses. The main use of cyclophosphamide is together with other chemotherapy agents in the treatment of lymphomas, some forms of leukemia and some solid tumors. In addition, its use is becoming more common in autoimmune dis ...

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Cyclophosphamide - Uses Cyclophosphamide - Pharmacokinetics Cyclophosphamide - Mode of action Cyclophosphamide - Side-effects Cyclophosphamide - History Cyclophosphamide - Reference

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Cyclophosphamide, Cyclophosphamide - Uses, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Mode of action, Cyclophosphamide - Side-effects, Cyclophosphamide - History, Cyclophosphamide - Reference

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The main use of cyclophosphamide is together with other chemotherapy agents in the treatment of lymphomas, some forms of leukemia and some solid tumors. In addition, its use is becoming more common in autoimmune diseases where disease-modifying antirheumatic drugs (DMARDs) have been ineffective. Systemic lupus erythematosus (SLE) with severe lupus nephritis, for example, may respond to pulsed cyclophosphamide. ...

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Cyclophosphamide, Cyclophosphamide - Uses, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Mode of action, Cyclophosphamide - Side-effects, Cyclophosphamide - History, Cyclophosphamide - Reference

Read more here: » Cyclophosphamide: Encyclopedia II - Cyclophosphamide - Uses

Side-effects include chemotherapy-induced nausea and vomiting (CINV), bone marrow suppression, alopecia (hair loss) and lethargy. Hemorrhagic cystitis is a frequent complication, but this is prevented by adequate fluid intake and mesna (sodium 2-mercaptoethane sulfonate). Mesna is a sulfhydryl donor and binds acrolein. Cyclophosphamide is itself carcinogenic, potentially causing transitional cell carc ...

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Cyclophosphamide, Cyclophosphamide - Uses, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Mode of action, Cyclophosphamide - Side-effects, Cyclophosphamide - History, Cyclophosphamide - Reference

Read more here: » Cyclophosphamide: Encyclopedia II - Cyclophosphamide - Side-effects