Conn's syndrome

Conn's syndrome: Encyclopedia - Conn's syndrome

Conn's syndrome is overproduction of the mineralocorticoid hormone aldosterone by the adrenal glands. Aldosterone causes sodium and water retention and potassium excretion in the kidneys, leading to arterial hypertension (high blood pressure). It is a rare but recognised cause of nonessential hypertension. It is named after Dr Jerome W. Conn (1907-1981), the American endocrinologist who first described the condition in 1955. It is the most common form of primary Hyperaldosteronism. Conn's syndrome - Signs symptoms and fi ...

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Conn's syndrome - Signs symptoms and findings

Conn's syndrome - Diagnosis

Conn's syndrome - Causes

Conn's syndrome - Therapy

Conn's syndrome - Reference

Conn's syndrome: Encyclopedia II - Conn's syndrome - Diagnosis Measuring aldosterone alone is not considered adequate to diagnose Conn's syndrome. Rather, both renin and aldosteron are measured, and the ratio is diagnostic. Usually, renin levels are suppressed, leading to a very low renin-aldosterone ratio (<0.05). This test is confounded by antihypertensive drugs, which have to be stopped up to 6 weeks. If there is biochemic proof of hyperaldosteronism, CT scanning ca ...

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Adrenal gland - Overview

Adrenal gland - Adrenal medulla

Adrenal gland - Adrenal cortex

Adrenal gland - Zona fasciculata

Adrenal gland - Zona reticularis

Adrenal gland - Pathology

Adrenal gland - Blood supply

Adrenal gland - Related topics

Conn's syndrome: Encyclopedia - Antiandrogen

An antiandrogen, or androgen antagonist, is any of a group of hormone antagonist compounds that are capable of preventing or inhibiting the biologic effects of androgens, male sex hormones, on normally responsive tissues in the body (see androgen insensitivity syndrome). Antiandrogens usually work by blocking the appropriate receptors, competing for binding sites on the cell's surface, obstructing the androgens' pathway. Antiandrogens are often indicated to treat severe male sexual disorders, such as hypersexuality (exce ...

Conn's syndrome: Encyclopedia - Adrenal gland

In mammals, the adrenal glands (also known as suprarenal glands or colloquially as kidney hats) are the triangle-shaped endocrine glands that sit atop the kidneys; their name indicates that position (ad, "near" or "at" + renes, "kidneys"). They are chiefly responsible for regulating the stress response through the synthesis of corticosteroids and catecholamines, including cortisol and adrenaline. Adrenal gland - Overview. Anatomically, the adrenal glands are located in the abdome ...

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Adrenal gland - Overview

Adrenal gland - Adrenal medulla

Adrenal gland - Adrenal cortex

Adrenal gland - Zona glomerulosa

Adrenal gland - Zona fasciculata

Adrenal gland - Zona reticularis

Adrenal gland - Pathology

Adrenal gland - Blood supply

Adrenal gland - Related topics

Conn's syndrome: Encyclopedia II - Endocrinology - Background

As evolution drove the emergence of multicellular organisms it became necessary to develop “coordinating systems to regulate and integrate the function of differentiating cells” (Griffin and Ojeda 2000). Two mechanisms perform this function in higher animals, the nervous system and the endocrine system. Unlike the former, which sends and receives information via electrochemical signals, the endocrine system performs its regulatory function through the detection, production and release (generally into the bloodstream) of chemical agents. ...

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Conn's syndrome

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