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Clinical trials | A Wisdom Archive on Clinical trials | | Clinical trials A selection of articles related to Clinical trials | |
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clinical trials
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| ARTICLES RELATED TO Clinical trials | | | | |  Clinical trials: Encyclopedia II - Bupropion - HistoryBupropion was first synthesized by Burroughs Research in 1966, and patented by Burroughs-Wellcome (later Glaxo-Wellcome, and, as of 2000, GlaxoSmithKline) in 1974. It was approved by the FDA in 1985 and marketed under the name Wellbutrin as an antidepressant, but clinical trials indicated that incidence of seizure was two to four times greater than other antidepressants and the drug was quickly pulled from the market. It was subsequently discovered that reducing the dose by about half greatly reduced the risk of seizures. Glaxo then d ...
See also:Bupropion, Bupropion - History, Bupropion - Mode of action, Bupropion - Pharmacokinetics, Bupropion - Chronic hepatotoxicity in animals, Bupropion - Indications, Bupropion - Contraindications, Bupropion - Side effects, Bupropion - Interactions, Bupropion - Abuse liability, Bupropion - Additional warnings, Bupropion - Dosage, Bupropion - Remarks, Bupropion - Dose forms Read more here: » Bupropion: Encyclopedia II - Bupropion - History |
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| | | | | Clinical trials: Encyclopedia II - Adverse effect medicine - Reporting systems In many countries, adverse effects are required by law to be reported, researched in clinical trials and included into the patient information accompanying medical devices and drugs for sale to the public.
Adverse effect medicine - USA.
In the USA several reporting systems have been built, such as the Vaccine Adverse Event Reporting System (VAERS), the Manufacturer and User Facility Device Experience Database (MAUDE) and the Special Nutritionals Adverse Event Monitoring System.
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See also:Adverse effect medicine, Adverse effect medicine - Reporting systems, Adverse effect medicine - USA, Adverse effect medicine - Australia, Adverse effect medicine - Adverse effects of medical procedures, Adverse effect medicine - Adverse effects of drugs, Adverse effect medicine - Controversies, Adverse effect medicine - Examples of adverse effects Read more here: » Adverse effect medicine: Encyclopedia II - Adverse effect medicine - Reporting systems |
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| | | | | | Clinical trials: Encyclopedia II - Sildenafil - History Sildenafil, initially known as compound UK-92,480, was initially developed to treat angina pectoris (a form of cardiovascular disease). Phase I clinical trials suggested that the drug had little effect on angina, but that it could induce marked penile erections. Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the FDA on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offer ...
See also:Sildenafil, Sildenafil - History, Sildenafil - Mechanism of action, Sildenafil - Dosage and price, Sildenafil - Contraindications and side effects, Sildenafil - Uses outside of erectile dysfunction, Sildenafil - Pulmonary hypertension, Sildenafil - Raynaud's phenomenon Read more here: » Sildenafil: Encyclopedia II - Sildenafil - History |
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| | | | | | Clinical trials: Encyclopedia II - Medical malpractice - Trial of claims Although medical malpractice is most often thought of as applying to physicians, the term includes the medical negligence of any medical care provider, including, for example, dentists, nurses, and therapists. Claims may also be brought against hospitals, clinics, or medical corporations for direct liability or for vicarious liability for the negligence of an employee.
In common with other forms of claims for negligence, in order to succeed in a claim (lawsuit) against a provider, the claimant (plaintiff) must successfully demonstrate ...
See also:Medical malpractice, Medical malpractice - Trial of claims, Medical malpractice - United States political controversy, Medical malpractice - History of the insurance debate, Medical malpractice - Today Read more here: » Medical malpractice: Encyclopedia II - Medical malpractice - Trial of claims |
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| | | | | Clinical trials: Encyclopedia II - Flecainide - Serious adverse reactions Results of a medical study known as the Cardiac Arrhythmia Suppression Trial (CAST) demonstrated that patients with structural heart disease (such as a history of MI (heart attack), or LV Dysfuction) and also patients with ventricular arrythmias, should not take this drug. In patients with these kinds of heart diseases, flecainide actually increases the chance of suffering a fatal arrythmia.
The dose may need to be adjusted in certain clinical scenarios. As with all other antiarrhythmic agents, there is a risk of proarrhythmia associa ...
See also:Flecainide, Flecainide - Uses, Flecainide - Dosing, Flecainide - Mechanism of action, Flecainide - Metabolism and drug interactions, Flecainide - Serious adverse reactions, Flecainide - Toxicity, Flecainide - Long term effects Read more here: » Flecainide: Encyclopedia II - Flecainide - Serious adverse reactions |
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| | | | | | | Clinical trials: Encyclopedia II - Atherosclerosis - Recent research Progress on methods to improve HDLipoprotein particle concentrations and function, which in some animal studies largely reverses and remove atheromas, are being developed and researched. The most dramatic demonstrations of potential HDL efficacy to reverse atherosclerosis has been with the rare Apo-A1 Milano human genetic variant of the HDL protein. Ongoing work starting in the 1990s, leading to human clinical trials probably by about 2008, on using either synthesized Apo-A1 Milano HDL directly or gene-transfer methods to pass the ability to synth ...
See also:Atherosclerosis, Atherosclerosis - Symptoms, Atherosclerosis - Atherogenesis, Atherosclerosis - Cellular, Atherosclerosis - Calcification and lipids, Atherosclerosis - Visible features, Atherosclerosis - Stenosis and rupture, Atherosclerosis - Diagnosis of plaque-related disease, Atherosclerosis - Risk factors, Atherosclerosis - Treatment, Atherosclerosis - Recent research Read more here: » Atherosclerosis: Encyclopedia II - Atherosclerosis - Recent research |
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| | | | | Clinical trials: Encyclopedia II - Amyotrophic lateral sclerosis - Treatment No cure has yet been found for ALS. However, the Food and Drug Administration (FDA) has approved the first drug treatment for the disease: riluzole (Rilutek). Riluzole is believed to reduce damage to motor neurons by decreasing the release of glutamate. Clinical trials with ALS patients showed that riluzole prolongs survival by several months, mainly in those with difficulty swallowing. The drug also extends the time before a patient needs ventilation support. Riluzole does not reverse the damage already done to motor neurons, and patients t ...
See also:Amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis - Epidemiology, Amyotrophic lateral sclerosis - Symptoms, Amyotrophic lateral sclerosis - Diagnosis, Amyotrophic lateral sclerosis - Cause, Amyotrophic lateral sclerosis - Treatment, Amyotrophic lateral sclerosis - Organizations, Amyotrophic lateral sclerosis - Famous people with ALS Read more here: » Amyotrophic lateral sclerosis: Encyclopedia II - Amyotrophic lateral sclerosis - Treatment |
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| | | | | Clinical trials: Encyclopedia II - SAS Institute - Company Although the advent of more powerful personal computers has also allowed lower cost statistical packages to be available, SAS software continues to be the standard used in statistical analysis of clinical pharmaceutical trials for submission to the Food and Drug Administration. It is also widely used for statistical analysis in the insurance industry and the field of public health, at least partially due to the powerful data import, handling, and manipulation functions added to the base package over the years, to extend the analytical capabi ...
See also:SAS Institute, SAS Institute - History, SAS Institute - Company, SAS Institute - SAS User Groups, SAS Institute - Other Strategies, SAS Institute - Community Read more here: » SAS Institute: Encyclopedia II - SAS Institute - Company |
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| | | | | Clinical trials: Encyclopedia II - Relative risk - Association with odds ratio Relative risk is different from odds ratio, although asymptotically approaches odds ratio for small probabilities. In fact, odds ratio has much wider use in statistics, since logistic regression, often associated with clinical trials, works with odds ratio, not relative risk. For example, in logistic regression model where the treatment outcome is associated with drug and age, and odds ratio for 70-year-olds and 60-year-olds associated with type of treatment would be the same, ...
See also:Relative risk, Relative risk - Statistical use and meaning, Relative risk - Association with odds ratio, Relative risk - Reference, Relative risk - External link Read more here: » Relative risk: Encyclopedia II - Relative risk - Association with odds ratio |
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| | | | | Clinical trials: Encyclopedia II - Harold Shipman - Detection In March 1998, Dr Linda Reynolds of the Brooke Surgery in Hyde, opposite Shipman's clinic, went to John Pollard, the coroner for the South Manchester district, with concerns about the high death rate among Shipman's patients (in particular the large number of cremation forms for elderly women that he had needed countersigning). She said that he was "killing" his patients, although she was not sure whether it was malpractice or malice. The matter was brought to the attention of the police, who were unable to find sufficient evidence to bring ...
See also:Harold Shipman, Harold Shipman - Early life, Harold Shipman - Detection, Harold Shipman - Trial and imprisonment, Harold Shipman - Suicide, Harold Shipman - Aftermath Read more here: » Harold Shipman: Encyclopedia II - Harold Shipman - Detection |
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