 | Corticotropin-releasing hormone: Encyclopedia - Corticotropin-releasing hormone
Corticotropin-releasing hormone
Corticotropin-releasing hormone (CRH), also called corticotropin-releasing factor (CRF) or corticoliberin, is a polypeptide hormone involved in the stress response.
It is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce ACTH and other biologically active substances (for example β-endorphin). CRH is also synthesized by the placenta and seems to determine the duration of pregnancy.
CRH is a hypophysiotropin that has behavioral effects at the paraventricular nucleus of the hypothalamus, the central nucleus of the amygdala, the bed nucleus of the stria terminalis, and at the locus coeruleus. Release of CRH is affected by serum levels of cortisol and leptin, by stress and by the sleep/wake cycle.
The 41-amino acid sequence of CRH was first determined by Shibahara et al in 1983.
Ser - Glu - Glu - Pro - Pro - Ile - Ser - Leu - Asp - Leu - Thr - Phe - His - Leu - Leu - Arg - Glu - Val - Leu - Glu - Met - Ala - Arg - Ala - Glu - Gln - Leu - Ala - Gln - Gln - Ala - His - Ser - Asn - Arg - Lys - Leu - Met - Glu - Ile - IleNH2
Corticotropin-releasing hormone - Reference
- Shibahara S, Morimoto Y, Furutani Y, Notake M, Takahashi H, Shimizu S, Horikawa S, Numa S. Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. EMBO J 1983;2:775-9. PMID 6605851.
Proopiomelanocortin, Hypothalamic-pituitary-adrenal axis
See also
- Proopiomelanocortin
- Hypothalamic-pituitary-adrenal axis
Hypothalamus: GnRH - TRH - CRH - GHRH - somatostatin | Posterior pituitary: ADH - oxytocin | Anterior pituitary: GH - ACTH - TSH - LH - FSH - prolactin - MSH
Thyroid: T3 and T4 - calcitonin | Parathyroid: PTH | Adrenal medulla: epinephrine - norepinephrine | Adrenal cortex: aldosterone - cortisol | Pancreas: insulin - glucagon | Ovary: estradiol - progesterone - inhibin - activin | Testis: testosterone - AMH | Pineal gland: melatonin
Stomach: gastrin | Duodenum: CCK - GIP - secretin - motilin - VIP | Ileum: enteroglucagon
Categories: Peptide hormones | Hormones of the hypothalamus | HPA axis
Other related archives1983, ACTH, ADH, AMH, Adrenal cortex, Adrenal medulla, Anterior pituitary, CCK, Duodenum, FSH, GH, GHRH, GIP, GnRH, HPA axis, Hormones of the hypothalamus, Hypothalamic-pituitary-adrenal axis, Hypothalamus, Ileum, LH, MSH, Ovary, PTH, Pancreas, Parathyroid, Peptide hormones, Pineal gland, Posterior pituitary, Proopiomelanocortin, Stomach, T3 and T4, TRH, TSH, Testis, Thyroid, VIP, activin, aldosterone, amino acid, amygdala, anterior lobe, calcitonin, cortisol, enteroglucagon, epinephrine, estradiol, gastrin, glucagon, hormone, hypothalamus, inhibin, insulin, leptin, locus coeruleus, melatonin, motilin, norepinephrine, oxytocin, paraventricular nucleus, pituitary, placenta, polypeptide, pregnancy, progesterone, prolactin, secretin, serum, somatostatin, stress, stress response, stria terminalis, testosterone, β-endorphin
 Adapted from the Wikipedia article "Corticotropin-releasing hormone", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
