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Syphilis - Treatment |  | Syphilis - Treatment: Encyclopedia II - Syphilis - Treatment |  | There were originally no effective treatments for syphilis. The most common in use were guaiacum and mercury: the use of mercury gave rise to the saying "A night in the arms of Venus leads to a lifetime on Mercury". Though no proper studies were done to prove it, mercury may have been an effective means to treat syphilis. It was administered multiple ways including by mouth and by rubbing it on the skin. One of the more fascinating methods was fumigation, in which the patient was placed in a closed box with their head sticking out. Mercury w ...
See also:Syphilis, Syphilis - History, Syphilis - Stages of syphilis, Syphilis - Primary syphilis, Syphilis - Secondary syphilis, Syphilis - Tertiary syphilis, Syphilis - Latent syphilis, Syphilis - Congenital syphilis, Syphilis - Testing, Syphilis - Treatment, Syphilis - Syphilis in art and literature |  | | Syphilis, Syphilis - Congenital syphilis, Syphilis - History, Syphilis - Latent syphilis, Syphilis - Primary syphilis, Syphilis - Secondary syphilis, Syphilis - Stages of syphilis, Syphilis - Syphilis in art and literature, Syphilis - Tertiary syphilis, Syphilis - Testing, Syphilis - Treatment, yaws is a tropical disease characterized by an infection of the skin, bones and joints; it is caused by a spirochete bacterium, Treponema pallidum, sp. pertenue, also called Treponema pertenue, an additional treponematous disease is called pinta and is caused by Treponema carateum. |  | |
|  |  | Syphilis: Encyclopedia II - Syphilis - Treatment
Syphilis - Treatment
There were originally no effective treatments for syphilis. The most common in use were guaiacum and mercury: the use of mercury gave rise to the saying "A night in the arms of Venus leads to a lifetime on Mercury". Though no proper studies were done to prove it, mercury may have been an effective means to treat syphilis. It was administered multiple ways including by mouth and by rubbing it on the skin. One of the more fascinating methods was fumigation, in which the patient was placed in a closed box with their head sticking out. Mercury was placed in the box and a fire was started under the box which caused the mercury to vaporize. It was a gruelling process for the patient and the least effective for delivering mercury to the body.
As the disease became better understood, more effective treatments were found, beginning with the use of the arsenic-containing drug Salvarsan from 1910, and later, Neosalvarsan.
Unfortunately, these drugs were not 100% effective, especially in late disease. It had been observed that some who develop high fevers could be cured of syphilis. Thus, for a brief time malaria was used as treatment because it produces prolonged and high fevers. This was considered an acceptable risk because the malaria could later be treated with quinine which was available at that time. Malaria as a treatment for syphilis was usually reserved for late disease, especially neurosyphilis, and then followed by either Salvarsan or Neosalvarsan as adjuvunct therapy.
These treatments were finally rendered obsolete by the discovery of penicillin, and its widespread manufacture after World War II allowed syphilis to be effectively cured for the first time.
To this day, the first choice treatment for syphilis remains penicillin, in the form of benzathine penicillin G or aqueous procaine penicillin G injections. Individuals who have severe allergic reactions to penicillin (e.g., anaphylaxis) may be effectively treated with oral tetracyclines.
Oral Azithromycin given as a single dose of 2g has been used successfully to treat syphilis in a pilot study of 328 patients in Tanzania (Riedner 2005), but resistance to azithromycin has been reported in the US and elsewhere, which makes it doubtful that this treatment will become widespread in the US.
Other related archives13, 1494, 14th, 1530, 1906, 1910, 1930s, 1998, 19th century, 20th century, A Doll's House, Adolf Hitler, Al Capone, Alcatraz, Arabs, Argyll-Robertson pupils, Augustinian, Azithromycin, CDC, Candide, Cardiovascular, Charles VIII, Charlotte Brontë, Christians, Christopher Columbus, Classical Greece, Congenital syphilis, English, French, Friedrich Nietzsche, Ghosts, Girolamo Fracastoro, Guy de Maupassant, Henrik Ibsen, Hippocrates, Hutchinson's teeth, Italian, Jane Eyre, Journal of the American Medical Association, July 17, Kees van Dongen, Kingston upon Hull, Leonardo da Vinci, List of notable people identified as probably syphilitic, Measure for Measure, Native Americans, Neapolitan, Neosalvarsan, Neurological, Paul Gauguin, Polish, Russians, Salvarsan, Science, Tabes dorsalis, Treponema pallidum, Tuskegee syphilis study, Voltaire, Wassermann test, William Shakespeare, World War II, Yaws, anaphylaxis, anarchist, aneurysm of sinus of Valsalva, anorexia, antibiotics, aortic aneurysm, aortic regurgitation, arsenic, art, asymptomatic, azithromycin, bacterium, black Americans, brain, chancre, condylomata, congenital, dementia, disease, fever, flocculation, general paresis of the insane, genome, guaiacum, gummas, headache, heart, hepatitis, immunofluorescence, in utero, insanity, literature, locomotor ataxia, lymph nodes, malaise, malaria, manufacture, meningismus, meningitis, mercury, monoclonal antibodies, novel, penicillin, penis, pinta, play, poem, procaine, pulmonary hemorrhage, quinine, rectum, satirize, serological testing, sexually transmitted disease, shepherd, smallpox, sore throat, spirochaete, tetracyclines, vagina, weight loss, yaws
 Adapted from the Wikipedia article "Treatment", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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