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Sulfonylurea - Uses | | Sulfonylurea - Uses: Encyclopedia II - Sulfonylurea - Uses | | Sulfonylureas are used almost exclusively in diabetes mellitus type 2. Other types of diabetes generally do not respond to sulfonylurea therapy, or (in diabetes of pregnancy) there are other contraindications.
Although for many years sulfonylureas were the first drugs to be used in new cases of diabetes, in the 1990s it was discovered that obese patients might benefit more from metformin.
In about 10% of patients, sulfonylureas alone are ineffective in controlling blood glucose levels. Addition of metformin or a thiazolidinedio ...
See also:Sulfonylurea, Sulfonylurea - Drugs in this class, Sulfonylurea - Chemistry, Sulfonylurea - Pharmacology, Sulfonylurea - Method of action, Sulfonylurea - Pharmacokinetics, Sulfonylurea - Uses, Sulfonylurea - Side-effects and cautions, Sulfonylurea - History | | | Sulfonylurea, Sulfonylurea - Chemistry, Sulfonylurea - Drugs in this class, Sulfonylurea - History, Sulfonylurea - Method of action, Sulfonylurea - Pharmacokinetics, Sulfonylurea - Pharmacology, Sulfonylurea - Side-effects and cautions, Sulfonylurea - Uses, diabetes mellitus, metformin, thiazolidinediones | | |
| | | Sulfonylurea: Encyclopedia II - Sulfonylurea - Uses
Sulfonylurea - Uses
Sulfonylureas are used almost exclusively in diabetes mellitus type 2. Other types of diabetes generally do not respond to sulfonylurea therapy, or (in diabetes of pregnancy) there are other contraindications.
Although for many years sulfonylureas were the first drugs to be used in new cases of diabetes, in the 1990s it was discovered that obese patients might benefit more from metformin.
In about 10% of patients, sulfonylureas alone are ineffective in controlling blood glucose levels. Addition of metformin or a thiazolidinedione may be necessary, or (ultimately) insulin. Triple therapy of sulfonylureas, a biguanide (metformin) and a thiazolidinedione is generally discouraged, but some doctors prefer this combination over resorting to insulin.
Other related archives1990s, ATP, Ca, Chlorpropamide, Glibenclamide, Glimepiride, Glipizide, K, Tolazamide, Tolbutamide, adipose tissue, antibiotics, antidiabetic drugs, beta cells, cytochrome P450, depolarization, dextrose, diabetes mellitus, diabetes of pregnancy, fatty acids, headache, hypoglycemia, insulin, intravenous, liver, metformin, obese, pancreas, phenyl, rifampicin, sulfonamide, teratogenic, thiazolidinedione, thiazolidinediones
 Adapted from the Wikipedia article "Uses", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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