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Sulfonylurea - Side-effects and cautions | | Sulfonylurea - Side-effects and cautions: Encyclopedia II - Sulfonylurea - Side-effects and cautions | | Sulfonylureas, as opposed to metformin and the thiazolidinediones, can induce hypoglycemia when insulin production overshoots. It is treated with sugary food, or (in the case of hypoglycemic coma) with intravenous dextrose. The best way to prevent this side-effect is to choose the lowest possible dose that adequately controls glucose levels.
Like insulin, sulfonylureas can induce weight gain, mainly as a result of fluid retention and improvement of osmotic diuresis. Other side-effects ar ...
See also:Sulfonylurea, Sulfonylurea - Drugs in this class, Sulfonylurea - Chemistry, Sulfonylurea - Pharmacology, Sulfonylurea - Method of action, Sulfonylurea - Pharmacokinetics, Sulfonylurea - Uses, Sulfonylurea - Side-effects and cautions, Sulfonylurea - History | | | Sulfonylurea, Sulfonylurea - Chemistry, Sulfonylurea - Drugs in this class, Sulfonylurea - History, Sulfonylurea - Method of action, Sulfonylurea - Pharmacokinetics, Sulfonylurea - Pharmacology, Sulfonylurea - Side-effects and cautions, Sulfonylurea - Uses, diabetes mellitus, metformin, thiazolidinediones | | |
| | | Sulfonylurea: Encyclopedia II - Sulfonylurea - Side-effects and cautions
Sulfonylurea - Side-effects and cautions
Sulfonylureas, as opposed to metformin and the thiazolidinediones, can induce hypoglycemia when insulin production overshoots. It is treated with sugary food, or (in the case of hypoglycemic coma) with intravenous dextrose. The best way to prevent this side-effect is to choose the lowest possible dose that adequately controls glucose levels.
Like insulin, sulfonylureas can induce weight gain, mainly as a result of fluid retention and improvement of osmotic diuresis. Other side-effects are: abdominal upset, headache and hypersensitivy reactions.
Sulfonylureas are potentially teratogenic and cannot be used in pregnancy or in patients who intend to get pregnant. Impairment of liver or kidney function increase the risk of hypoglycemia, and are contraindications. As other anti-diabetic drugs cannot be used either under these circumstances, insulin therapy is the only option in pregnancy and hepatic and renal failure.
Other related archives1990s, ATP, Ca, Chlorpropamide, Glibenclamide, Glimepiride, Glipizide, K, Tolazamide, Tolbutamide, adipose tissue, antibiotics, antidiabetic drugs, beta cells, cytochrome P450, depolarization, dextrose, diabetes mellitus, diabetes of pregnancy, fatty acids, headache, hypoglycemia, insulin, intravenous, liver, metformin, obese, pancreas, phenyl, rifampicin, sulfonamide, teratogenic, thiazolidinedione, thiazolidinediones
 Adapted from the Wikipedia article "Side-effects and cautions", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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