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St John's wort - Pharmacology | | St John's wort - Pharmacology: Encyclopedia II - St John's wort - Pharmacology | | The exact mechanism by which St. John's wort — and even conventional antidepressants — function is unclear and subject to much conjecture.
The St. John's wort mechanism is believed to involve inhibition of Serotonin (5-HT) reuptake, much like the conventional SSRI antidepressants.
The major active constituents in St John's wort are thought to be hyperforin and hypericin, although other biologically active constituents present, e.g. flavonoids and tannins, may also ...
See also:St John's wort, St John's wort - The plant, St John's wort - Uses of the herb, St John's wort - Clinical evidence, St John's wort - Evidence for efficacy, St John's wort - Evidence against efficacy, St John's wort - Pharmacology, St John's wort - Dose/Formulations, St John's wort - Adverse effects, St John's wort - Drug interactions, St John's wort - Pharmacokinetic interactions, St John's wort - Pharmacodynamic interactions | | | St John's wort, St John's wort - Adverse effects, St John's wort - Clinical evidence, St John's wort - Dose/Formulations, St John's wort - Drug interactions, St John's wort - Evidence against efficacy, St John's wort - Evidence for efficacy, St John's wort - Pharmacodynamic interactions, St John's wort - Pharmacokinetic interactions, St John's wort - Pharmacology, St John's wort - The plant, St John's wort - Uses of the herb, Dietary supplement, EU Food supplements directive | | |
| | | St John's wort: Encyclopedia II - St John's wort - Pharmacology
St John's wort - Pharmacology
The exact mechanism by which St. John's wort — and even conventional antidepressants — function is unclear and subject to much conjecture.
The St. John's wort mechanism is believed to involve inhibition of Serotonin (5-HT) reuptake, much like the conventional SSRI antidepressants.
The major active constituents in St John's wort are thought to be hyperforin and hypericin, although other biologically active constituents present, e.g. flavonoids and tannins, may also be involved. (Nahrstedt & Butterweck, 1997)
Hyperforin is believed to be the major constituent responsible for antidepressant activity, and has been shown to inhibit the uptake of 5-HT, dopamine, noradrenaline, GABA and glutamate. (Chatterjee et al., 1998a) Discrepancies in the dose-response relationship imply that constituents other than hyperforin are likely to also be involved. (Chatterjee et al., 1998b)
Other related archives2, 4-D, 24 June, 5-HT, CYP3A4, Clusiaceae, Cochrane Review, DSM-IV, Dietary supplement, Food supplements directive, GABA, Germany, Hamilton Depression Rating Scale, Hyperforin, Hypericaceae, Hypericum, NIH, Native Americans, North America, SSRI, Serotonin (5-HT), St John's, abortifacient, ancient Greece, antidepressants, anxiety disorders, biocontrol, central nervous system, clinical depression, cytochrome P450, depression, dopamine, dye, flavonoids, genus, glutamate, glyphosate, homeopathy, hyperforin, hypericin, meta-study, noradrenaline, over the counter, perennial, photosensitivity, placebos, rhizomatous, serotonin syndrome, sertraline, species, tablet, tannins, tinctures, tricyclic antidepressants
 Adapted from the Wikipedia article "Pharmacology", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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