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Riluzole - Mechanism of action | | Riluzole - Mechanism of action: Encyclopedia II - Riluzole - Mechanism of action | | Riluzole has several actions:
Sodium channel blockade
High-voltage calcium channel blockade
N-methyl-D-aspartate (NMDA)/glutamate receptor blockade
Riluzole preferentially blocks TTX-S sodium channels, which are associated with damaged neurons. This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors. Together with direct glutamate receptor blockade, the effect of the neurotransmitte ...
See also:Riluzole, Riluzole - Mechanism of action, Riluzole - Studies of efficacy, Riluzole - Clinical use | | | Riluzole, Riluzole - Clinical use, Riluzole - Mechanism of action, Riluzole - Studies of efficacy | | |
| | | Riluzole: Encyclopedia II - Riluzole - Mechanism of action
Riluzole - Mechanism of action
Riluzole has several actions:
- Sodium channel blockade
- High-voltage calcium channel blockade
- N-methyl-D-aspartate (NMDA)/glutamate receptor blockade
Riluzole preferentially blocks TTX-S sodium channels, which are associated with damaged neurons. This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors. Together with direct glutamate receptor blockade, the effect of the neurotransmitter glutamate on motor neurons is greatly reduced.
Other related archivesCochrane Library, NHS, NMDA, OCD, Sodium, amyotrophic lateral sclerosis, antidepressant, calcium, channel, cigarettes, depression, drug, glutamate, hepatitis, ions, liver function tests, muscle, nausea, neurons, neurotransmitter, patients, plasma, quality of life, tracheostomy, ventilator
 Adapted from the Wikipedia article "Mechanism of action", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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