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Pemetrexed - Mechanism of action | | Pemetrexed - Mechanism of action: Encyclopedia II - Pemetrexed - Mechanism of action | | Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyl transferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the growth a ...
See also:Pemetrexed, Pemetrexed - Mechanism of action, Pemetrexed - Clinical use | | | Pemetrexed, Pemetrexed - Clinical use, Pemetrexed - Mechanism of action | | |
| | | Pemetrexed: Encyclopedia II - Pemetrexed - Mechanism of action
Pemetrexed - Mechanism of action
Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyl transferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
The molecular structure of pemetrexed was developed by Edward C. Taylor at Princeton University and clinically developed by Indianapolis based drug maker, Eli Lilly and Company.
Other related archivesB12, DNA, Eli Lilly and Company, February 2004, Food and Drug Administration, July 2004, Princeton University, RNA, antimetabolites, chemotherapy, cisplatin, dihydrofolate reductase, folic acid, lung cancer, mesothelioma, non-small cell lung cancer, nucleotides, pleural, purine, pyrimidine
 Adapted from the Wikipedia article "Mechanism of action", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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