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Lorazepam - Pharmacological Data and Pharmacokinetics | | Lorazepam - Pharmacological Data and Pharmacokinetics: Encyclopedia II - Lorazepam - Pharmacological Data and Pharmacokinetics | | Lorazepam is rapidly and nearly completely absorbed after any mode of application (oral, sublingual, i.m., i.v.). After i.v.-injection onset of action is within minutes and may be delayed to 30-45 minutes after oral/sublingual dose and up to 1 hour after i.m. use.
The duration of action depends on the dose and is normally 6 to 12 hours. The half-life of lorazepam in patients with normal liver function is 11 to 18 hours. Therefore, 2-4 daily doses are often needed.
A dose equivalent to 5 mg of diazepam is 500 micrograms (0.5 mg) of lorazepam. [1]. Other experts estim ...
See also:Lorazepam, Lorazepam - Indications, Lorazepam - Pharmacological Data and Pharmacokinetics, Lorazepam - Dosage, Lorazepam - Disadvantages, Lorazepam - Abuse, Lorazepam - Legal issues | | | Lorazepam, Lorazepam - Abuse, Lorazepam - Disadvantages, Lorazepam - Dosage, Lorazepam - Indications, Lorazepam - Legal issues, Lorazepam - Pharmacological Data and Pharmacokinetics | | |
| | | Lorazepam: Encyclopedia II - Lorazepam - Pharmacological Data and Pharmacokinetics
Lorazepam - Pharmacological Data and Pharmacokinetics
Lorazepam is rapidly and nearly completely absorbed after any mode of application (oral, sublingual, i.m., i.v.). After i.v.-injection onset of action is within minutes and may be delayed to 30-45 minutes after oral/sublingual dose and up to 1 hour after i.m. use.
The duration of action depends on the dose and is normally 6 to 12 hours. The half-life of lorazepam in patients with normal liver function is 11 to 18 hours. Therefore, 2-4 daily doses are often needed.
A dose equivalent to 5 mg of diazepam is 500 micrograms (0.5 mg) of lorazepam. [1]. Other experts estimate a proportion of 1 to 5 (5mg diazepam equivalent to 1 mg lorazepam).
Other related archives2000, C, CAS number, Cl, Controlled Substances Act, Convention on Psychotropic Substances, F.T.C., FDA, GABA, H, LSD, Mylan, N, O, Premedication, U.S., Wyeth, alcohol withdrawal, alprazolam, anterograde amnesia, anticonvulsant, antiemetics, anxiety disorders, anxiolytic, bad trip, benzodiazepine, catatonic states, chemotherapy, clonazepam, clorazepate, date rape drug, delirium, depressions, detox, diazepam, disinhibition, emesis, flunitrazepam, formula, generic, half-life, hallucinogens, haloperidol, heroin, insomnia, intramuscular, intravenous, liver, mania, nausea, opioids, paradoxical, patent, personality disorders, petit mal epilepsy, potency, psychotherapy, psychotic disorders, sedative, seizures, status epilepticus
 Adapted from the Wikipedia article "Pharmacological Data and Pharmacokinetics", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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