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Loop diuretic - Mechanism of action | | Loop diuretic - Mechanism of action: Encyclopedia II - Loop diuretic - Mechanism of action | | Loop diuretics act on the Na+/K+/Cl- cotransporter in the ascending loop of Henle to inhibit sodium and chloride reabsorption. Because magnesium and calcium reabsorption in the thick ascending loop is dependent on sodium and chloride concentrations, loop diuretics also inhibit their reabsorption. This raises the osmotic pressure inside the loop, driving more water into the filtrate causing increased urine volume.
Loop diuretics also cause vasodilation of the veins and of the kidney's blood vessel ...
See also:Loop diuretic, Loop diuretic - Mechanism of action, Loop diuretic - Clinical use, Loop diuretic - Loop diuretic resistance, Loop diuretic - Adverse effects, Loop diuretic - Examples of loop diuretics | | | Loop diuretic, Loop diuretic - Adverse effects, Loop diuretic - Clinical use, Loop diuretic - Examples of loop diuretics, Loop diuretic - Loop diuretic resistance, Loop diuretic - Mechanism of action | | |
| | | Loop diuretic: Encyclopedia II - Loop diuretic - Mechanism of action
Loop diuretic - Mechanism of action
Loop diuretics act on the Na+/K+/Cl- cotransporter in the ascending loop of Henle to inhibit sodium and chloride reabsorption. Because magnesium and calcium reabsorption in the thick ascending loop is dependent on sodium and chloride concentrations, loop diuretics also inhibit their reabsorption. This raises the osmotic pressure inside the loop, driving more water into the filtrate causing increased urine volume.
Loop diuretics also cause vasodilation of the veins and of the kidney's blood vessels, mechanically causing a decrease in blood pressure.
The collective effects of increased urine production and vasodilation decrease blood pressure and ameliorate edema.
Other related archivesACE inhibitor, Bumetanide, Cl, Ethacrynic acid, Furosemide, IV, K, NSAID, Na, Ototoxicity, blood pressure, blood vessels, calcium, cerebral, cirrhosis, congestive heart failure, creatinine, deafness, dehydration, diuresis, diuretics, dizziness, dyslipidemia, ear, edema, electrolyte, glomerular filtration rate, gout, heart failure, hydrochlorothiazide, hypercalcemia, hypertension, hyperuricemia, hypokalemia, hypomagnesemia, hyponatremia, kidney, loop of Henle, magnesium, medicine, nephrotic syndrome, non-steroidal anti-inflammatory drugs, osmotic pressure, postural hypotension, pulmonary edema, rash, renal impairment, renal insufficiency, syncope, thiazide, tinnitus, urine, vasodilation, veins, vertigo
 Adapted from the Wikipedia article "Mechanism of action", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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