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Heroin - History

Heroin - History: Encyclopedia II - Heroin - History

Heroin was first synthesized in 1874 by C.R. Alder Wright, a British chemist working at St. Mary's Hospital Medical School, London. He had been experimenting with combining morphine with various acids. He boiled anhydrous morphine alkaloid with acetic anhydride over a stove for several hours and produced a more potent, acetylated form of morphine. We now call it diacetylmorphine. The compound was sent to F.M. Pierce of Owens College, Manchester, for analysis. He reported the following to Wright: Doses … were subcutan ...

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Heroin, Heroin - History, Heroin - Usage and effects, Heroin - Production and trafficking, Heroin - Manufacturing, Heroin - History, Heroin - Trafficking, Heroin - Risks of non-medical abuse of heroin, Heroin - Withdrawal, Heroin - Drug interactions, Heroin - Culture, Heroin - Books

Heroin, Heroin - Books, Heroin - Culture, Heroin - Drug interactions, Heroin - History, Heroin - Manufacturing, Heroin - Production and trafficking, Heroin - Risks of non-medical abuse of heroin, Heroin - Trafficking, Heroin - Usage and effects, Heroin - Withdrawal, Black Tar Heroin, Hillbilly Heroin, China White, Methadone, Recreational drug use, Psychoactive drug, Scag, List of famous opiate addicts, List of famous drug smugglers, Opium, Poppy

Heroin: Encyclopedia II - Heroin - History



Heroin - History

Heroin was first synthesized in 1874 by C.R. Alder Wright, a British chemist working at St. Mary's Hospital Medical School, London. He had been experimenting with combining morphine with various acids. He boiled anhydrous morphine alkaloid with acetic anhydride over a stove for several hours and produced a more potent, acetylated form of morphine. We now call it diacetylmorphine. The compound was sent to F.M. Pierce of Owens College, Manchester, for analysis. He reported the following to Wright:

Doses … were subcutaneously injected into young dogs and rabbits … with the following general results … great prostration, fear, and sleepiness speedily following the administration, the eyes being sensitive, and pupils dilated, considerable salivation being produced in dogs, and slight tendency to vomiting in some cases, but no actual emesis. Respiration was at first quickened, but subsequently reduced, and the heart's action was diminished, and rendered irregular. Marked want of coordinating power over the muscular movements, and loss of power in the pelvis and hind limbs, together with a diminution of temperature in the rectum of about 4°(rectal failure) [2]

Heinrich Dreser, of Bayer in Elberfeld, Germany, noticed that diacetylmorphine was more potent than morphine. Bayer registered Heroin (meaning 'heroic treatment' from the German word heroisch) as a trademark. From 1898 through to 1910 it was marketed as a non-addictive morphine substitute and cough medicine for children. As with Aspirin, Bayer lost some of its trademark rights to Heroin following World War I.

In 1914 the Harrison Narcotics Tax Act made it illegal to manufacture or possess heroin in the United States.

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Adapted from the Wikipedia article "History", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki

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