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Haemophilia A - Diagnosis | | Haemophilia A - Diagnosis: Encyclopedia II - Haemophilia A - Diagnosis | | The diagnosis may be suspected as coagulation testing reveals an increased PTT in the context of a normal PT and bleeding time. The diagnosis is made in the presence of very low (<10 IU) levels of factor VIII. A family history is frequently present, although not essential. Nowadays, genetic testing may also be performed.
The most important differential diagnosis is that of hemophilia B (also known as Christmas disease) or von Willebrand disease. The former is usually considered if factor VIII levels are normal in a person with a haemophilia phenotype. The latter is excl ...
See also:Haemophilia A, Haemophilia A - Signs and symptoms, Haemophilia A - Diagnosis, Haemophilia A - Therapy | | | Haemophilia A, Haemophilia A - Diagnosis, Haemophilia A - Signs and symptoms, Haemophilia A - Therapy | | |
| | | Haemophilia A: Encyclopedia II - Haemophilia A - Diagnosis
Haemophilia A - Diagnosis
The diagnosis may be suspected as coagulation testing reveals an increased PTT in the context of a normal PT and bleeding time. The diagnosis is made in the presence of very low (<10 IU) levels of factor VIII. A family history is frequently present, although not essential. Nowadays, genetic testing may also be performed.
The most important differential diagnosis is that of hemophilia B (also known as Christmas disease) or von Willebrand disease. The former is usually considered if factor VIII levels are normal in a person with a haemophilia phenotype. The latter is excluded on routine testing for that condition.
A very small minority of patients has antibodies against factor VIII that impair its functioning. Management of these patients is more complicated (see below).
Other related archivesPT, PTT, Port-a-Cath, Recently, X-linked, antibodies, bleeding time, blood, brain, clotting, desmopressin, differential diagnosis, digestive tract, factor VII, factor VIII, family history, genetic testing, hemophilia, hemophilia B, intravenous, joints, muscles, phenotype, recombinant, von Willebrand disease
 Adapted from the Wikipedia article "Diagnosis", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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