 | Ethosuximide: Encyclopedia - Ethosuximide
Ethosuximide
ethosuximide
Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures. It is sold by Pfizer under the name Zarontin®.
Ethosuximide - Adverse Effects
Ethosuximide - Central Nervous System
- drowsiness
- mental confusion
- insomnia
- nervousness
- headache
- euphoria
- ataxia
- hiccups
- impaired concentration
- irritability
- hyperactivity
- loss of taste
- night terrors
- paranoid psychosis
- increased libido
- exacerbation of depression
Ethosuximide - Gastrointestinal
- dyspepsia
- vomiting
- nausea
- cramps
- constipation
- diarrhea
- stomach pain
- loss of appetite
- weight loss
- gingival hyperplasia
- swelling of tongue
Ethosuximide - Genitourinary
- microscopic hematuria
- vaginal bleeding
Ethosuximide - Hematopoietic
The following can occur with or without bone marrow loss:
- pancytopenia
- agranulocytosis
- leukopenia
- eosinophilia
Ethosuximide - Integumentary
- urticaria
- systemic lupus erythematosus
- Stevens-Johnson syndrome
- hirsutism
- pruritic erythematous rashes
Ethosuximide - Ocular
Ethosuximide - Complications
Ethosuximide - Drug Interactions
Valproates can either decrease or increase the levels of ethosuximide; However, combinations of valproates and ethosuximide had a greater Protective Index than either drug alone.[3]
It may elevate serum phenytoin levels.
Ethosuximide - End Notes
- ^ Ethosuximide PubChem Substance Summary.
- ^ Patsalos PN. "Properties of Antiepileptic Drugs in the Treatment of Idiopathic Generalized Epilepsies." Epilepsia 2005 Nov;46(s9):140-144. Volume 46 Issue s9 Page 140 - November 2005 PMID 16302888
- ^ Bourgeois BF. "Combination of valproate and ethosuximide: antiepileptic and neurotoxic interaction." The Journal of Pharmacology and Experimental Therapeutics. 1988 Dec;247(3):1128-32. PMID 3144596
{Lamotrigine}
{Primidone}
{Potassium bromide}
{Paraldehyde}
{Valpromide} {Valnoctamide}
{Topiramate}
{Beclamide}
{Stiripentol}
{Carbamazepine} {Oxcarbazepine}
{Pheneturide} {Phenacemide}
{Gabapentin} {Vigabatrin} {Progabide} {Pregabalin}
{Trimethadione} {Paramethadione} {Ethadione}
{Brivaracetam} {Levetiracetam} {Nefiracetam} {Seletracetam}
{Ethotoin} {Phenytoin} {Mephenytoin} {Fosphenytoin}
{Acetazolamide} {Sultiame} {Methazolamide} {Zonisamide}
{Felbamate} {Meprobamate} {Emylcamate} {Phenprobamate}
{Ethosuximide} {Phensuximide} {Mesuximide}
{Valproic acid} {Sodium valproate} {Valproate semisodium} {Tiagabine}
{Amobarbital} {Aprobarbital} {Butabarbital} {Butalbital} {Hexobarbital} {Mephobarbital} {Pentobarbital} {Phenobarbital} {Phenytoin} {Secobarbital} {Sodium thiopental} {Talbutal} {Thiobarbital}
{Diazepam} {Oxazepam} {Nitrazepam} {Temazepam} {Lorazepam} {Flunitrazepam} {Bromazepam} {Clobazam} {Clonazepam} {Chlordiazepoxide} {Triazolam} {Midazolam} {Alprazolam} {Estazolam} {Quazepam} {Clorazepate} {Medazepam} {Prazepam} {Flurazepam}
Other related archivesAcetazolamide, Alprazolam, Amobarbital, Beclamide, Bromazepam, Butabarbital, Butalbital, Carbamazepine, Chlordiazepoxide, Clobazam, Clonazepam, Clorazepate, Diazepam, Emylcamate, Estazolam, Ethotoin, Felbamate, Flunitrazepam, Flurazepam, Fosphenytoin, Gabapentin, Lamotrigine, Levetiracetam, Lorazepam, Mephobarbital, Meprobamate, Midazolam, Nefiracetam, Nitrazepam, Oxazepam, Oxcarbazepine, Paraldehyde, Pentobarbital, Pfizer, Phenobarbital, Phenprobamate, Phenytoin, Potassium bromide, Pregabalin, Primidone, Progabide, Quazepam, Secobarbital, Sodium thiopental, Sodium valproate, Stevens-Johnson syndrome, Stiripentol, Talbutal, Temazepam, Thiobarbital, Tiagabine, Topiramate, Triazolam, Valnoctamide, Valproate semisodium, Valproates, Valproic acid, Valpromide, Vigabatrin, Zonisamide, absence seizures, agranulocytosis, anticonvulsant, ataxia, constipation, depression, diarrhea, dyspepsia, eosinophilia, erythematous rashes, euphoria, gingival hyperplasia, headache, hematuria, hirsutism, hyperactivity, insomnia, leukopenia, liver function, myopia, nausea, night terrors, pancytopenia, paranoid, phenytoin, pruritic, psychosis, succinimide, systemic lupus erythematosus, urticaria, valproates, vomiting
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