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Dofetilide - Mechanism of action | | Dofetilide - Mechanism of action: Encyclopedia II - Dofetilide - Mechanism of action | | Dofetilide works by selectively blocking the rapid component of the delayed rectifier outward potassium current (IKr).
This causes prolongation of the effective refractory period of accessory pathways (both anterograde and retrograde conduction in the accessory pathway). It is this selective action on accessory pathways that makes dofetilide effective in the treatment of atrial fibrillation and flutter.
Dofetilide does not effect Vmax (The slope of the upstroke of phase 0 depolarization), condu ...
See also:Dofetilide, Dofetilide - Mechanism of action, Dofetilide - Metabolism, Dofetilide - Side effects, Dofetilide - Clinical use | | | Dofetilide, Dofetilide - Clinical use, Dofetilide - Mechanism of action, Dofetilide - Metabolism, Dofetilide - Side effects, Antiarrhythmic agents, Cardiac action potential, Electrocardiogram | | |
| | | Dofetilide: Encyclopedia II - Dofetilide - Mechanism of action
Dofetilide - Mechanism of action
Dofetilide works by selectively blocking the rapid component of the delayed rectifier outward potassium current (IKr).
This causes prolongation of the effective refractory period of accessory pathways (both anterograde and retrograde conduction in the accessory pathway). It is this selective action on accessory pathways that makes dofetilide effective in the treatment of atrial fibrillation and flutter.
Dofetilide does not effect Vmax (The slope of the upstroke of phase 0 depolarization), conduction velocity, or the resting membrane potential.
There is a dose-dependant increase in the QT interval and the corrected QT interval (QTc). Because of this, many practitioners will initiate dofetilide therapy only on individuals under telemetry monitoring or if serial EKG measurements of QT and QTc can be performed.
Other related archivesAntiarrhythmic agents, CYP3A4, Cardiac action potential, Cytochrome P450, Electrocardiogram, FDA, Pfizer, Torsades de pointes, United States, antiarrhythmic agent, atrial fibrillation, cardioversion, cimetidine, creatinine, creatinine clearance, flutter, half-life, itraconazole, ketoconazole, kidneys, left ventricular, myocardial infarction, prochlorperazine, renal insufficiency, slope, telemetry, trimethoprim, verapamil, µg
 Adapted from the Wikipedia article "Mechanism of action", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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