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Cyclophosphamide - Mode of action | | Cyclophosphamide - Mode of action: Encyclopedia II - Cyclophosphamide - Mode of action | | The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells which have low levels of aldehyde dehydrogenase.
Phosphoramide mustard forms DNA crosslinks between and within DNA strands. This leads to cell death.
Cyclophosphamide has relatively little typical chemotherapy toxicity, as ALDH is present in relatively large concentrations in bone marrow stem cells, liver and intestinal epithelium, prot ...
See also:Cyclophosphamide, Cyclophosphamide - Uses, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Mode of action, Cyclophosphamide - Side-effects, Cyclophosphamide - History, Cyclophosphamide - Reference | | | Cyclophosphamide, Cyclophosphamide - History, Cyclophosphamide - Mode of action, Cyclophosphamide - Pharmacokinetics, Cyclophosphamide - Reference, Cyclophosphamide - Side-effects, Cyclophosphamide - Uses | | |
| | | Cyclophosphamide: Encyclopedia II - Cyclophosphamide - Mode of action
Cyclophosphamide - Mode of action
The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells which have low levels of aldehyde dehydrogenase.
Phosphoramide mustard forms DNA crosslinks between and within DNA strands. This leads to cell death.
Cyclophosphamide has relatively little typical chemotherapy toxicity, as ALDH is present in relatively large concentrations in bone marrow stem cells, liver and intestinal epithelium, protecting these tissues against phosphoramide mustard.
Other related archivesALKYLATING AGENTS, ANTI-METABOLITES, ANTITUMOUR ANTIBIOTICS, Azathioprine, Bleomycin, Busulfan, Capecitabine, Carboplatin, Chemotherapeutic agents, Chlorambucil, Cisplatin, Cytarabine, Daunorubicin, Docetaxel, Doxorubicin, Epirubicin, Etoposide, Fludarabine, Fluorouracil, Gemcitabine, Hydroxyurea, Idarubicin, Irinotecan, Mechlorethamine, Melphalan, Methotrexate, Mitomycin, Mitoxantrone, Oxaliplatin, PLANT ALKALOIDS, Paclitaxel, Pemetrexed, Side-effects, Systemic lupus erythematosus, TOPOISOMERASE INHIBITORS, Vinblastine, Vincristine, Vinorelbine, acrolein, actively transported, alkylating agent, alopecia, autoimmune diseases, autoimmune disorders, bladder, bone marrow stem cells, bone marrow suppression, cancer, carcinogenic, carcinoma, chemotherapeutic, chemotherapy-induced nausea and vomiting, disease-modifying antirheumatic drugs, enzymatically, enzymes, epithelium, equilibrium, hemorrhagic cystitis, intestinal, lethargy, leukemia, liver, lupus nephritis, lymphomas, mesna, nitrogen mustard, oxidase, prodrug, tautomer
 Adapted from the Wikipedia article "Mode of action", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki |
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