Consciousness: Encyclopedia II - Consciousness - Cognitive neuroscience approaches

Consciousness - Cognitive neuroscience approaches

Modern investigations into and discoveries about consciousness are based on psychological statistical studies and case studies of consciousness states and the deficits caused by lesions, stroke, injury, or surgery that disrupt the normal functioning of human senses and cognition. These discoveries suggest that the mind is a complex structure derived from various localized functions that are bound together with a unitary awareness.

Several studies point to common mechanisms in different clinical conditions that lead to loss of consciousness. Persistent vegetative state (PVS) is a condition in which an individual loses the higher cerebral powers of the brain, but maintains sleep-wake cycles with full or partial autonomic functions. Studies comparing PVS with healthy, awake subjects consistently demonstrate an impaired connectivity between the deeper (brainstem and thalamic) and the upper (cortical) areas of the brain. In addition, it is agreed that the general brain activity in the cortex is lower in the PVS state. Some electroneurobiological interpretations of consciousness characterize this loss of consciousness as a loss of the ability to resolve time (similar to playing an old phonographic record at very slow or very rapid speed), along a continuum that starts with inattention, continues on sleep, and arrives to coma and death.

Loss of consciousness also occurs in other conditions, such as general (tonic-clonic) epileptic seizures, in general anaesthesia, maybe even in deep (slow-wave) sleep. At present, the best-supported hypotheses about such cases of loss of consciousness (or loss of time resolution) focus on the need for 1) a widespread cortical network, including particularly the frontal, parietal and temporal cortices, and 2) cooperation between the deep layers of the brain, especially the thalamus, and the upper layers, the cortex. Such hypotheses go under the common term "globalist theories" of consciousness, due to the claim for a widespread, global network necessary for consciousness to interact with non-mental reality in the first place.

Brain chemistry affects human consciousness. Sleeping drugs (such as Midazolam = Dormicum) can bring the brain from the awake condition (conscious) to the sleep (unconscious). Wake-up drugs such as Anexate reverse this process. Many other drugs (such as alcohol, nicotine, THC, heroin, cocaine, LSD, MDMA) have a consciousness-changing effect.

There is a neural link between the left and right hemispheres of the brain, known as the corpus callosum. This link is sometimes surgically severed to control severe seizures in epilepsy patients. This procedure was first performed by Roger Sperry in the 1960's. Tests of these patients have shown that, after the link is completely severed, the hemispheres are no longer able to communicate, leading to certain problems that usually arise only in test conditions. For example, while the left side of the brain can verbally describe what is going on in the right visual field, the right hemisphere is essentially mute, instead relying on its spatial abilities to interact with the world on the left visual field. Some say that it is as if two separate minds now share the same skull, but both still represent themselves as a single "I" to the outside world.

The bilateral removal of the Centromedian nucleus (part of the Intra-laminar nucleus of the Thalamus) appears to abolish consciousness, causing coma, PVS, severe mutism and other features that mimic brain death. The centromedian nucleus is also one of the principal sites of action of general anaesthetics and anti-psychotic drugs.

Neurophysiological studies in awake, behaving monkeys performed by neuroscientists point to advanced cortical areas in prefrontal cortex and temporal lobes as carriers of neuronal correlates of consciousness. Christof Koch and Francis Crick argued that neuronal mechanisms of consciousness are intricatly related to prefrontal cortex — the most advanced cortical area. Experimental work of Steven Wise, Mikhail Lebedev and their colleagues supports this view. They demonstrated that activity of prefrontal cortex neurons reflects illusory perceptions of movements of visual stimuli. Nikos Logothetis and colleagues made similar observations on visually responsive neurons in the temporal lobe. These neurons reflect the visual perception in the situation when conflicting visual images are presented to different eyes (i.e., bistable percepts during binocular rivalry). The studies of blindsight — vision without awareness after lesions to parts of the visual system such as the primary visual cortex — performed by Lawrence Weiskrantz and David P. Carey provided important insights on how conscious perception arises in the brain. In recent years the theory of two visual streams, vision for perception versus vision for action was developed by Melvyn Goodale, David Milner and others. According to this theory, visual perception arises as the result of processing of visual information by the ventral stream areas (located mostly in the temporal lobe), whereas the dorsal stream areas (located mostly in the parietal lobe) process visual information unconsciously. For example, quick catching of the ball would engage mostly the dorsal stream areas, and viewing a painting would be handled by the ventral stream. Overal, these studies show that conscious versus unconscious behaviors can be linked to specific brain areas and patterns of neuronal activation.

Adapted from the Wikipedia article "Cognitive neuroscience approaches", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki