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Chagas disease - Clinical manifestations

Chagas disease - Clinical manifestations: Encyclopedia II - Chagas disease - Clinical manifestations

The human disease occurs in two stages: the acute stage shortly after the infection. A local lesion (so called chagoma (see picture), palpebral edema) can appear at the site of inoculation. The acute phase is usually asymptomatic, but can present with manifestations that include fever, anorexia, lymphadenopathy, mild hepatosplenomegaly, and myocarditis. Some acute cases (10 to 20%) resolve over a period of 2 to 3 months into an asympto ...

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Chagas disease, Chagas disease - History, Chagas disease - Epidemiology and geographical distribution, Chagas disease - Clinical manifestations, Chagas disease - Infection cycle, Chagas disease - Alternative infection mechanism, Chagas disease - Laboratory diagnosis, Chagas disease - Treatment, Chagas disease - Prevention, Chagas disease - Original publication, Chagas disease - Sources

Chagas disease, Chagas disease - Alternative infection mechanism, Chagas disease - Clinical manifestations, Chagas disease - Epidemiology and geographical distribution, Chagas disease - History, Chagas disease - Infection cycle, Chagas disease - Laboratory diagnosis, Chagas disease - Original publication, Chagas disease - Prevention, Chagas disease - Sources, Chagas disease - Treatment, Tropical disease, In Jalisco, Huichol -Indians used to eat reduviid bugs in hot sauce. In other mexican communities there is a believe, that the bugs feces can cure warts or that the bugs have aphrodisiac powers.

Chagas disease: Encyclopedia II - Chagas disease - Clinical manifestations

Chagas disease - Clinical manifestations

The human disease occurs in two stages: the acute stage shortly after the infection. A local lesion (so called chagoma (see picture), palpebral edema) can appear at the site of inoculation. The acute phase is usually asymptomatic, but can present with manifestations that include fever, anorexia, lymphadenopathy, mild hepatosplenomegaly, and myocarditis. Some acute cases (10 to 20%) resolve over a period of 2 to 3 months into an asymptomatic chronic stage, only to reappear after several years.

The symptomatic chronic stage may not occur for years or even decades after initial infection. The disease affects the nervous system, digestive system and heart. Chronic infections result in various neurological disorders, including dementia, damage to the heart muscle (cardiomyopathy, the most serious manifestation), and sometimes dilation of the digestive tract (megacolon and megaesophagus), as well as weight loss. Swallowing difficulties may be the first symptom of digestive disturbances and may lead to malnutrition. After several years of an asymptomatic period, 27% of those infected develop cardiac damage, 6% develop digestive damage, and 3% present peripheral nervous involvement. Left untreated, Chagas disease can be fatal, in most cases due to the cardiomyopathy component.

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Adapted from the Wikipedia article "Clinical manifestations", under the G.N U Free Docmentation License. Please also see http://en.wikipedia.org/wiki

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